FB2024_03 , released June 25, 2024
Allele: Dmel\Su(var)2-1207
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General Information
Symbol
Dmel\Su(var)2-1207
Species
D. melanogaster
Name
FlyBase ID
FBal0016497
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Su(var)207
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes show an increase in crossing over between kni and pp. Heterozygotes show an increase in crossing over between se and kni, between kni and ss and between ss and e. Heterozygotes show an increase in crossing over between y and N. Heterozygous females show reduced disjunction and/or chromosome loss in oogenesis compared to controls.

Moderate maternal effects as seen by elevated w+ eye pigment levels in non-suppressor bearing offspring of Su(var)2-1 females. Removal of segments of heterochromatin from the genome by loss of the Y chromosome abolishes the suppression of the position effect variegation phenotype. The extent of hemizygous lethality is dramatically enhanced in the presence of extra heterochromatin ( attachedXX/Y females) whereas the lethality did not occur in the absence of the Y (X/O males). The effect of the Su(var)2-1207 allele is unchanged in heterozygotes with Df(2R)M41A10 (which lacks 2R heterochromatin). Viability of the Su(var)2-1207 heterozygotes is butyrate-sensitive.

Moderate enhancer of variegation at the lt locus.

Su(var)2-1207; Dp(2;2)Mdh3 double mutants display reductions in eye pigmentation.

Dominant suppressor of position effect variegation at the w locus caused by In(1)wm4.

homozygous lethal

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Originally isolated as a dominant suppressor of the w+ gene on In(1)wm4.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)