FB2024_03 , released June 25, 2024
Allele: Dmel\spz3
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General Information
Symbol
Dmel\spz3
Species
D. melanogaster
Name
FlyBase ID
FBal0016061
Feature type
allele
Associated gene
Dmel\spz
Associated Insertion(s)
Carried in Construct
Also Known As
spz67
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Morisato and Anderson, 1994)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q207R.

(Weber et al., 2007)

Nucleotide substitution: A620G.

(Weber et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:27,066,114..27,066,114 [-]
Nucleotide change:

A27066114G

Reported nucleotide change:

A620G

Amino acid change:

Q263R | spz-PA; Q237R | spz-PB; Q190R | spz-PC; Q210R | spz-PD; Q164R | spz-PI; Q181R | spz-PJ; Q227R | spz-PK; Q207R | spz-PL

Reported amino acid change:

Q207R

(Weber et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      VA1d olfactory receptor neuron axon targeting is normal in mutant flies.

      (Ward et al., 2015)

      Embryonic lethal when heterozygous with the MBT chromosome.

      (Riede, 2001)

      Affected embryos show preferential loss of ventral structures and the expansion of lateral and dorsal structures.

      (Morisato and Anderson, 1994)

      Embryos derived from spz2/spz3 females are weakly dorsalised at 18oC. The mesoderm and ventral furrow are reduced in size, and mesoderm only develops in the posterior part of the embryo.

      (Leptin and Grunewald, 1990)

      temperature-sensitive Temperature-sensitive period of spz3 extends from oogenesis through fertilization until about the time of pole-cell formation

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      spz3, srn88 has lethal | pupal stage phenotype

      (Riede, 2001)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      spz3/pll2, spz3/pll8 or spz3/pll1 does not result in neoplasms.

      (Riede, 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      spzMBT

      (Riede, 2001)

      spzMBT

      (Riede, 1996)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (10)