FB2024_03 , released June 25, 2024
Allele: Dmel\snw
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General Information
Symbol
Dmel\snw
Species
D. melanogaster
Name
weak
FlyBase ID
FBal0015885
Feature type
allele
Associated gene
Dmel\sn
Associated Insertion(s)
P{}sn-w-a
P{}sn-w-b
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Lindsley and Zimm, 1992, Roiha et al., 1988)
Progenitor genotype
Associated Insertion(s)
P{}sn-w-a
P{}sn-w-b
Cytology
Description

Contains a pair of adjacent defective P elements of 0.95 kb and 1.15 kb inserted in head-to-head orientation between -0.589 and -0.582 kb. All sne derivatives tested retain only the 1.15 kb element and all normal-appearing derivatives retain only the 0.95 kb element, thus the symbol sn(+).

(Lindsley and Zimm, 1992)

Contains two defective P-elements in tandem.

(Daniels et al., 1990)

Tandem insertion of two small P-elements.

(Rio, 1990)

Insertion of two inverted P-elements.

(Brookfield and Lewis, 1989)

Insertion of P-element.

(Georgiev and Gerasimova, 1989)

snw contains two P-element insertions, of 1.15kb and 0.95kb, inserted at the same site in inverted orientation, with only the 8bp duplication (in this case of sn sequence) usually found bounding an inserted P-element between them. The insertion is in the region -2.0 to 0.0.

(Roiha et al., 1988)

Insertion of a 2 kb P element.

(Collins et al., 1983)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
X17548
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bristle phenotype is suppressed by su(s)71, and partly suppressed by su(s)sn-w:R.

      (Merriman et al., 1995)

      Repression potential of a P-element repressor protein in a singed sterility assay of snw/snX2 heterozygotes shows partial correspondence with gonadal dysgenic sterility in that strong repression of gonadal dysgenic sterility shows some effect in the singed sterility assay.

      (Misra et al., 1993)

      Weak singed phenotype, probably class 2. Highly mutable in dysgenic genotypes; 40% to 60% of offspring are either normal (sn(+)) or extreme singed (sne) in phenotype. These derivatives are in turn mutable, but at much lower levels. Completely stable in non-dysgenic genotypes. Gnarled macrochaetae and kinky microchaetae.

      (Lindsley and Zimm, 1992)

      The presence of P\T66 causes a drastic reduction in destabilisation of snw to sne or sn(+). This repression is not increased by P\T66D1.hs, but it is increased by P\T66C2.hs.

      (Misra and Rio, 1990)

      Can mutate during a dysgenic cross to either wild type phenotype or a more extreme (sne) bristle phenotype depending on which one of the P-elements excises.

      (Rio, 1990)

      Phenotype is unaffected by mod(mdg4)ul.

      (Georgiev and Gerasimova, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      snw has phenotype, non-enhanceable by ph-pP1

      (Biryukova et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The viability of Mnn1e200 mutants (Df(2L)Mnn1e200 mutants in which milt function is rescued by expression of the milt+22 transgene) is not affected by a snw background.

      (Busygina et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (8)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{Icarus} destabilises the mutation snw in germ line cells at a maximal rate even without heat shock. P{Icarus} does not destabilise snw in somatic cells.

      (Steller and Pirrotta, 1986)

      snw is hypermutable in the M cytotype, mutating either to a more extreme allele (sne), or reverting to wild type. This mutation rate can exceed 50%, with the two derivatives being generated at approximately equal rates. This hypermutability is probably due to the presence of two P-element insertions in snw.

      (Roiha et al., 1988)

      Some somatic reversion of this allele is seen. The rate of somatic reversion is 0.06%. The movements of the P-elements in these somatic reversions occur early in development, and require a trans-acting maternal effect component (P\TMo). Somatic reversion occurs preferentially in attached-X stocks.

      (Brookfield and Lewis, 1989)

      Unstable in the M cytotype in the presence of a transposase, mutating either to sne (a more extreme allele) or to sn+ (apparent wild-type).

      (Ronsseray et al., 1991)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      snw
      (Sameny et al., 2011, Jensen et al., 2008, Busygina et al., 2004)
      Name Synonyms
      weak
      Secondary FlyBase IDs
        References (51)