FlyBase Allele Report: Dmel\shakB[25]

General Information

Symbol

Dmel\shakB²⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0015598

Feature type

allele

Associated gene

Dmel\shakB

Associated Insertion(s)

Carried in Construct

Also Known As

HM437

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

hycanthon methanesulfonate

Nature of the Allele

Allele class

Mutagen

hycanthon methanesulfonate

(Perrimon et al., 1989, Kramers et al., 1983)

Progenitor genotype

Cytology

Description

Mutation in the lethal and neural common exons. Amino acid replacement: L299@. Nucleotide substitution: TTA to TAA.

(Krishnan et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:20,772,771..20,772,771 [-]

Nucleotide change:

T20772771A

Reported nucleotide change:

T?A

Amino acid change:

Reported amino acid change:

L299term

(Krishnan et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior

(Baird et al., 1990)

flightless

(Perrimon et al., 1989)

increased rate of movement

(Perrimon et al., 1989)

lethal | recessive

(Krishnan et al., 1995, Perrimon et al., 1989, Kramers et al., 1983)

uncoordinated

(Baird et al., 1990)

Phenotype Manifest In

dorsal longitudinal indirect flight muscle cell

(Krishnan et al., 1995)

tergotrochanter muscle cell

(Krishnan et al., 1995)

Detailed Description

Statement

Reference

The DLMs do not respond to brain shocks and the TTMs respond only occasionally and then with a longer than normal latency.

(Krishnan et al., 1995)

Abnormal electrophysiological phenotype. Homozygous flies exhibit uncoordinated leg movements under ether anaesthesia and do not jump to a light off stimulus. Heterozygotes are fully viable but exhibit some neuronal defects.

(Baird et al., 1990)

Lethality occurs during embryonic or larval stages. Homozygous germline clones display no maternal effect. Flies derived from heterozygous mothers are hyperactive and have trouble flying.

(Perrimon et al., 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

shakB²⁵, smi26D¹/smi26D[+] has abnormal locomotor behavior | dominant | female phenotype

(Anholt et al., 2003)

shakB²⁵, smi26D¹/smi26D[+] has abnormal smell perception | dominant | female phenotype