FB2024_03 , released June 25, 2024
Allele: Dmel\scHw-Ua
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General Information
Symbol
Dmel\scHw-Ua
Species
D. melanogaster
Name
FlyBase ID
FBal0015253
Feature type
allele
Associated gene
Dmel\sc
Associated Insertion(s)
copia{}scHw-Ua
Carried in Construct
Also Known As
Hwua
Key Links
Allele class

hypermorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypermorphic allele - genetic evidence

(Rabinow et al., 1993, Rabinow and Birchler, 1990)
Mutagen
spontaneous
(Lindsley and Zimm, 1992, Campuzano et al., 1986)
Progenitor genotype
sc1
(Lindsley and Zimm, 1992)
Associated Insertion(s)
copia{}scHw-Ua
Cytology
Description

Insertion of a copia element at position 904bp within the sc gene, near the end of the coding region.

(Ayyar et al., 2007)

Product lacks the C-terminal peptide.

(Cabrera et al., 1994)

Antiparallel copia insertion in an exon.

(Rabinow et al., 1993)

copia element insertion in the opposite orientation into an exon generating a truncated RNA.

(Rabinow and Birchler, 1990)

A copia insert into sc coding region. Complete copia element inserted into T4, the presumed sc structural gene, about one third of the distance from termination of the transcription unit. The scHw-Ua transcript carries the 5' two-thirds of the presumptive sc and terminates in copia. Transcript present in excess in early larvae but not in crawling larvae or early pupae.

(Campuzano et al., 1986)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies often have ectopic bristles on the notum at 18[o]C; 35% of heminota have one ectopic bristle and 35% of heminota have more than one ectopic bristle.

      (Ayyar et al., 2007)

      Doa mutants cause suppression of scHw-Ua and result in loss of scutellar bristles.

      (Rabinow et al., 1993)

      Differentiation of extra chaetes on the cuticle.

      (Campuzano et al., 1986)

      Weak acHw-1 phenotype in heterozygous females. Phenotype only slightly enhanced by suppressing the pre-existing sc1 allele with su(Hw)2.

      (Garcia Alonso and Garcia-Bellido, 1986)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      scHw-Ua has visible phenotype, enhanceable by RelE20

      (Ayyar et al., 2007)
      Enhancer of
      Statement
      Reference

      scHw-Ua is an enhancer of visible phenotype of RelE20

      (Ayyar et al., 2007)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      scHw-Ua has macrochaeta | ectopic phenotype, enhanceable by RelE20

      (Ayyar et al., 2007)

      scHw-Ua has mesothoracic tergum phenotype, enhanceable by RelE20

      (Ayyar et al., 2007)
      Enhancer of
      Statement
      Reference

      scHw-Ua is an enhancer of mesothoracic tergum phenotype of RelE20

      (Ayyar et al., 2007)

      scHw-Ua is an enhancer of macrochaeta | ectopic phenotype of RelE20

      (Ayyar et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      scHw-Ua RelE20 flies show one ectopic macrochaeta in 13% of heminota more than one ectopic macrochaeta in 85% of heminota analysed at 18[o]C.

      (Ayyar et al., 2007)

      Causes partial suppression of the sc phenotype. Mutations in su(f), E(wa) and mw had no effect on the phenotype.

      (Rabinow and Birchler, 1990)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Arose on: y2 sc1.

      (Lindsley and Zimm, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (9)