FlyBase Allele Report: Dmel\sc[1]

General Information

Symbol

Dmel\sc¹

Species

D. melanogaster

Name

FlyBase ID

FBal0015189

Feature type

allele

Associated gene

Dmel\sc

Associated Insertion(s)

gypsy{}sc¹

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Campuzano et al., 1985)

Progenitor genotype

Associated Insertion(s)

gypsy{}sc¹

Cytology

Description

gypsy insertion within an enhancer of the ac-sc complex.

(Cassidy et al., 2013)

Insertion of a gypsy element.

(Georgiev et al., 1990)

Insertion of gypsy element.

(Georgiev and Gerasimova, 1989)

gypsy at 1.9 to 2.4; (Carramolino, Ruiz-Gomez, Guerrero, Campuzano, and Modolell (1982) and Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat and Modolell (1985). 0 defined as the more distal EcoRI site within the sc^S2 molecular deficiency; positive values extend to the left.)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Georgiev and Gerasimova, 1989)

visible | adult stage, with Scer\GAL4^cv-c-C5, sc^SA.UAS.cQa

(Quan et al., 2016)

visible | adult stage, with Scer\GAL4^cv-c-C5, sc^UAS.cQa

(Quan et al., 2016)

visible | recessive

(Held, 1990, Fahmy and Fahmy, 1958)

Phenotype Manifest In

anterior dorsocentral bristle

(Georgiev and Gerasimova, 1989)

anterior orbital bristle

(Georgiev and Gerasimova, 1989)

mesothoracic tarsal bristle

(Held, 1990)

mesothoracic tarsal bristle longitudinal row 6

(Held, 1990)

mesothoracic tarsal bristle longitudinal row 6.5

(Held, 1990)

microchaeta | adult stage | increased number, with Scer\GAL4^cv-c-C5, sc^SA.UAS.cQa

(Quan et al., 2016)

microchaeta | adult stage | increased number, with Scer\GAL4^cv-c-C5, sc^UAS.cQa

(Quan et al., 2016)

middle orbital bristle

(Georgiev and Gerasimova, 1989)

ocellar bristle

(Georgiev and Gerasimova, 1989, Fahmy and Fahmy, 1958)

postocellar bristle

(Fahmy and Fahmy, 1958)

scutellar bristle

(Quan et al., 2016, Georgiev and Gerasimova, 1989)

scutellar bristle, with Scer\GAL4^cv-c-C5, sc^SA.UAS.cQa

(Quan et al., 2016)

scutellar bristle, with Scer\GAL4^cv-c-C5, sc^UAS.cQa

(Quan et al., 2016)

scutellar bristle | heat sensitive

(Cassidy et al., 2013)

wing

(Jack and DeLotto, 1992)

Detailed Description

Statement

Reference

sc¹ mutant adults do not display changes in the number of scutellar bristles, as compared to controls.

(Xu et al., 2019)

sc¹ mutants completely lack scutellar bristles. sc¹ mutant 'rescue' flies that express either sc^Scer\UAS.cQa or sc^{SA.Scer\UAS.cQa} under the control of Scer\GAL4^cv-c-C5 do not lack scutellar macrochaetae (although their number is decreased compared to wild-type) but in addition they also display ectopic short bristles on the scutellum.

(Quan et al., 2016)

The scutellar bristle fate show temperature dependence in sc¹ flies, with the probably of sensory bristle fate being inversely proportional to the temperature.

(Cassidy et al., 2013)

Homozygotes exhibit loss of a third to half of the wing margin chemoreceptors. Double mutants with ct^L32 exhibit an extreme wing phenotype lacking almost all the chemoreceptors and mechanoreceptors.

(Jack and DeLotto, 1992)

y²/y^59b flies carrying sc¹ on the y² chromosome have a y² phenotype.

(Geyer et al., 1990)

The number of bractless bristles on the basitarsi of the second legs is reduced.

(Held, 1990)

Flies show a loss or reduction in the number of scutellar, anterior dorsocentral, first and second orbital, ocellar and some other bristles.

(Georgiev and Gerasimova, 1989)

sc^Fah/sc¹ flies show only an occasional absence of postvertical or ocellar bristles.

(Fahmy and Fahmy, 1958)

Causes loss or marked reduction in number of scutellar, coxal, ocellar, first and second orbital, anterior notopleural, postvertical, tergital and sternal bristles. Bristle sockets missing; bristle cells absent 19 hr after pupation, when normally present (Lees and Waddington, 1942; Lees and Waddington, 1943). Suppressed by su(Hw) and su(Hw)². RK1. Revertable by X rays (Green, 1961).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

sc[+]/sc¹ is a suppressor of visible | dominant | adult stage phenotype of lncRNA:SMRG^M

(Xu et al., 2019)

sc[+]/sc¹ is a suppressor of visible | dominant | adult stage phenotype of E(spl)mβ-HLH^12-11

(Xu et al., 2019)

ac¹/sc¹ is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Other

Statement

Reference

Df(1)sc19, sc¹ has visible phenotype

(Mari-Beffa et al., 1991)

Df(1)260-1, sc¹ has visible phenotype

(Mari-Beffa et al., 1991)

Phenotype Manifest In

Enhanced by

Statement

Reference

sc¹ has scutellar bristle | heat sensitive phenotype, enhanceable by sens^E1/sens^m1

(Cassidy et al., 2013)

sc¹ has scutellar bristle | heat sensitive phenotype, enhanceable by sens^E1/sens^m2

(Cassidy et al., 2013)

sc¹ has scutellar bristle | heat sensitive phenotype, enhanceable by sens^E1/sens^m1m2

(Cassidy et al., 2013)

sc¹ has scutellar bristle | heat sensitive phenotype, enhanceable by mir-9a[+]/mir-9a^unspecified

(Cassidy et al., 2013)

Suppressed by

Statement

Reference

sc¹ has phenotype, suppressible by su(sc)r^u1

(Georgiev and Gerasimova, 1992)

sc¹ has phenotype, suppressible by su(sc)r^u2

(Georgiev and Gerasimova, 1992)

sc¹ has phenotype, suppressible by su(sc)r^u3

(Georgiev and Gerasimova, 1992)

sc¹ has phenotype, suppressible by su(Hw)^u2

(Georgiev and Gerasimova, 1989)

sc¹ has phenotype, suppressible by su(Hw)²

(Georgiev and Gerasimova, 1989, Lindsley and Grell, 1968)

sc¹ has phenotype, suppressible by su(Hw)^u1

(Georgiev and Gerasimova, 1989)

Suppressor of

Statement

Reference

sc[+]/sc¹ is a suppressor of scutellar bristle | increased number phenotype of lncRNA:SMRG^M

(Xu et al., 2019)

sc[+]/sc¹ is a suppressor of scutellar bristle | increased number phenotype of E(spl)mβ-HLH^12-11

(Xu et al., 2019)

sc[+]/sc¹ is a suppressor of wing margin bristle | ectopic phenotype of hry⁴¹/h[+], ttk^rM730

(Badenhorst et al., 2002)

ac¹/sc¹ is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

ac¹/sc¹ is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Other

Statement

Reference

Df(1)sc19, sc¹ has tergite phenotype

(Mari-Beffa et al., 1991)

Df(1)sc19, sc¹ has chaeta phenotype

(Mari-Beffa et al., 1991)

Df(1)260-1, sc¹ has tergite phenotype

(Mari-Beffa et al., 1991)

Df(1)260-1, sc¹ has chaeta phenotype

(Mari-Beffa et al., 1991)

Additional Comments

Genetic Interactions

Statement

Reference

Flies carrying either sens^m1, sens^m2 or sens^m1m2 in a sens^E1 background show enhanced temperature dependence of the scutellar bristle phenotype (loss of scutellar bristles) of sc¹ flies compared to controls carrying sens^+t18.1 in a sc¹ sens^E1 background.

mir-9a^unspecified/+ enhances the temperature dependence of the scutellar bristle phenotype (loss of scutellar bristles) of sc¹ flies.

(Cassidy et al., 2013)

The addition of sc¹/Y to h⁴¹/+, ttk^rM730/+ animals leads to an almost complete suppression of the ectopic margin bristle phenotype.

(Badenhorst et al., 2002)

The phenotype is affected by mod(mdg4)^ul; the ocellar, first and second orbital, and postvertical bristles are present, while the scutellar bristles are lost completely.

(Georgiev and Gerasimova, 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

sc¹ is partially rescued by sc^UAS.cQa/Scer\GAL4^cv-c-C5

(Quan et al., 2016)

sc¹ is partially rescued by Scer\GAL4^cv-c-C5/sc^SA.UAS.cQa

(Quan et al., 2016)

Not rescued by

sc¹ is not rescued by sc^SD.UAS.cQa/Scer\GAL4^cv-c-C5

(Quan et al., 2016)

Comments

The loss of scutellar macrochaetae characteristic for sc¹ mutant adults is partially rescued by expression of either sc^Scer\UAS.cQa or sc^{SA.Scer\UAS.cQa} (but not sc^{SD.Scer\UAS.cQa}) under the control of Scer\GAL4^cv-c-C5, which however also results in formation of ectopic short bristles on the scutellum.

(Quan et al., 2016)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type