FlyBase Allele Report: Dmel\sbr[12]

General Information

Symbol

Dmel\sbr¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0015176

Feature type

allele

Associated gene

Dmel\sbr

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

MRh12 induced male recombination

male recombination induced by dysgenesis

(Eeken et al., 1985)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Zhimulev et al., 1987)

lethal | heat sensitive (with sbr^ts148)

(Wilkie et al., 2001)

lethal | recessive

(Eeken et al., 1985)

partially lethal - majority die

(Qurashi et al., 2011)

Phenotype Manifest In

embryonic somatic muscle cell (with sbr^mgln)

(Korey et al., 2001)

larval intersegmental nerve

(Korey et al., 2001)

muscle cell of A1-7 ventral longitudinal muscle 3 (with sbr^mgln)

(Korey et al., 2001)

muscle cell of A1-7 ventral longitudinal muscle 4 (with sbr^mgln)

(Korey et al., 2001)

Detailed Description

Statement

Reference

sbr¹² homozygotes are largely lethal but heterozygotes display normal viability relative to wild-type controls.

(Qurashi et al., 2011)

Mutant embryos show pathfinding errors in the ISNb pathway. sbr¹²/sbr^mgln embryos show defects in muscle morphology (for example in muscles 6 and 7) at stage 16.

(Korey et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

sbr¹² is a non-suppressor of abnormal neuroanatomy | somatic clone phenotype of Hsap\TARDBP^{Q331K.UAS.cSa}, Scer\GAL4^VGlut-OK371

(Sreedharan et al., 2015)

Other

Statement

Reference

Scer\GAL4^elav-C155, Zzzz\CGG^60.UAS.EGFP, sbr¹²/sbr[+] has partially lethal - majority die phenotype

(Qurashi et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

sbr¹² is a suppressor of leg | somatic clone phenotype of Hsap\TARDBP^{Q331K.UAS.cSa}, Scer\GAL4^VGlut-OK371

(Sreedharan et al., 2015)

sbr¹² is a suppressor of motor neuron | somatic clone phenotype of Hsap\TARDBP^{Q331K.UAS.cSa}, Scer\GAL4^VGlut-OK371

(Sreedharan et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

sbr¹² does not suppress the degeneration seen in leg motor neuron clones expressing Hsap\TARDBP^{Q331K.Scer\UAS.cSa} under the control of Scer\GAL4^VGlut-OK371.

(Sreedharan et al., 2015)

sbr¹² heterozygotes expressing Zzzz\CGG^{60.Scer\UAS.T:Avic\GFP-EGFP} driven by Scer\GAL4^elav-C155 display reduced viability compared to controls. Neither of these manipulations alone causes any viability deficits.

(Qurashi et al., 2011)

Complementation and Rescue Data

Fails to complement

sbr^ts148

(Wilkie et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

5649

108350

Notes on Origin

Discoverer

Eeken.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

24/45A

(Eeken et al., 1985)

l(1)24/45A

(Pougatchova et al., 2002, Tretyakova et al., 2002, Mamon et al., 1999, Tretyakova and Mamon, 1998, Zhimulev, 1982)

sbr12

(Pougatchova et al., 2002)

sbr12^LOF

(Qurashi et al., 2011)

sbr¹²

(Sreedharan et al., 2015, Wilkie et al., 2001)

sbr^24/45A

(Zhimulev et al., 1987)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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