FlyBase Allele Report: Dmel\Polr2A[106]

General Information

Symbol

Dmel\Polr2A¹⁰⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0014763

Feature type

allele

Associated gene

Dmel\Polr2A

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Krasnoselskaya et al., 1998, Kim et al., 1994, Lindsley and Zimm, 1992)

Phenotype Manifest In

Detailed Description

Statement

Reference

RpII215¹⁰⁶/RpII215¹⁰⁶ females with a duplication for RpII215⁺ display about 50% normal viability and are fertile when crossed to wild type, but nearly sterile in crosses to RpII215^Ubl males with a duplication for RpII215⁺; all surviving progeny of the latter cross display a hyperabdominal-like phenotype; the females lack metathoracic legs and/or halteres in addition to having extra abdominal tissue; this phenotype barely detectable in offspring of crosses to normal males.

(Lindsley and Zimm, 1992)

Hyperabdominal-like phenotype.

(Mortin and Kaufman, 1982)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Polr2A¹⁰⁶ has lethal phenotype, non-suppressible by Polr2B^S1

(Kim et al., 1994)

Polr2A¹⁰⁶ has lethal phenotype, non-suppressible by Polr2B^S2

(Kim et al., 1994)

Polr2A¹⁰⁶ has lethal phenotype, non-suppressible by Polr2B^S5

(Kim et al., 1994)

Polr2A¹⁰⁶ has lethal phenotype, non-suppressible by Polr2B^S6

(Kim et al., 1994)

Polr2A¹⁰⁶ has lethal phenotype, non-suppressible by Polr2B^S8

(Kim et al., 1994)

Polr2A¹⁰⁶ has lethal phenotype, non-suppressible by Polr2B^S7

(Kim et al., 1994)

Polr2A¹⁰⁶ has lethal phenotype, non-suppressible by Polr2B^S11

(Kim et al., 1994)

Polr2A¹⁰⁶ has lethal phenotype, non-suppressible by Polr2B^S12

(Kim et al., 1994)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The recessive lethality of RpII215¹⁰⁶ is not rescued by one copy of RpII140^S1, RpII140^S2, RpII140^S5, RpII140^S6, RpII140^S8, RpII140^S7, RpII140^S11 or RpII140^S12.

(Kim et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Lefevre.

(Lindsley and Zimm, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Polr2A¹⁰⁶

RpII215¹⁰⁶

RpII^h

(Mortin and Kaufman, 1982)

Ubl^h

(Lindsley and Zimm, 1992)

l(1)DC783

(Lindsley and Zimm, 1992)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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