FlyBase Allele Report: Dmel\red[1]

General Information

Symbol

Dmel\red¹

Species

D. melanogaster

Name

FlyBase ID

FBal0014517

Feature type

allele

Associated gene

Dmel\red

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Amino acid replacement: N67H.

(Grant et al., 2016)

Nucleotide substitution: A14300442C.

(Grant et al., 2016)

The nucleotide position is from chromosome arm 3R (r6). The amino acid position listed is for isoforms PA, PD, and PE. In isoforms PB, PF, and PG, the position is N90H.

(Grant et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:14,300,441..14,300,441 [+]

Nucleotide change:

A14300441C

Reported nucleotide change:

A14300442C

Amino acid change:

Reported amino acid change:

N67H

Comment:

The nucleotide position is from chromosome arm 3R (r6). The amino acid position listed is for isoforms PA, PD, and PE. In isoforms PB, PF, and PG, the position is N90H. (Curator note- reported nucleotide position appears to be off by 1).

(Grant et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

abnormal eye color (with Df(3R)BSC487)

(Cook and Cook, 2014.8.7)

abnormal eye color (with Df(3R)Exel6267)

(Cook and Cook, 2014.8.7)

abnormal eye color | recessive

(Henikoff, 1979)

visible | recessive

Phenotype Manifest In

eye (with Df(3R)BSC487)

(Cook and Cook, 2014.8.7)

eye (with Df(3R)Exel6267)

(Cook and Cook, 2014.8.7)

Malpighian tubule

(Henikoff, 1979)

Malpighian tubule (with Df(3R)BSC487)

(Cook and Cook, 2014.8.7)

Malpighian tubule (with Df(3R)Exel6267)

(Cook and Cook, 2014.8.7)

pigment cell

(Henikoff, 1979)

Detailed Description

Statement

Reference

red¹/Df(3R)Exel6267 and red¹/Df(3R)BSC487 flies show both the eye and Malpighian tubule coloration of red¹ homozygotes.

(Cook and Cook, 2014.8.7)

Eye colour: dark brown. Malpighian tubule colour: red (larvae and adults).

(Henikoff, 1979)

Pigment of Malpighian tubules are ommochromes.

(Paton and Sullivan, 1975)

Eyes contain less drosopterin and isoxanthopterin and more of the other pteridines than normal. Eye color autonomous in red¹ eye discs transplanted into wild-type host. Wild-type Malpighian tubes acquire some red pigment after transplantation into red¹ hosts.

(Aslaksen and Hadorn, 1958)

RK1. Malpighian tubule colour: rusty red. Malpighian tubule colour: colourless, with v¹. Malpighian tubule colour: colourless, with cn¹. Eye colour: brown, darkening with age.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

red¹ has abnormal eye color | recessive phenotype, enhanceable by kar²

(Henikoff, 1979)

Enhancer of

Statement