FB2024_03 , released June 25, 2024
Allele: Dmel\βTub60DPin-1
Open Close
General Information
Symbol
Dmel\βTub60DPin-1
Species
D. melanogaster
Name
FlyBase ID
FBal0013831
Feature type
allele
Associated gene
Dmel\βTub60D
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Krishnan et al., 2021)
Mutagen
spontaneous
(Ives, 1940)
Progenitor genotype
Cytology
Description

Amino acid replacement: E75K.

(Krishnan et al., 2021)

Nucleotide substitution: ?223?.

(Krishnan et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      βTub60DPin-1 heterozygotes show shortened macrochaeta, which are sharply tapered at the tip; microchaeta are not affected. βTub60DPin-1 homozygotes, which die as pharate adults, as well as βTub60DPin-1/βTub60DM1, βTub60DPin-1/Df(2R)Exel6082, βTub60DPin-1/Df(2R)nvyPDFKG1 and βTub60DPin-1/Df(2R)nvyPDFKG38 transheterozygotes also show shorter bristles.

      Unlike controls, in βTub60DPin-1 heterozygous pupae, microtubules are not evenly distributed along the bristle shaft and often appear as aggregates at various locations; microtubule defects are also evident in βTub60DPin-1/Df(2R)Exel6082 transheterozygotes.

      (Krishnan et al., 2021)

      Thoracic bristles, especially dorso-centrals and scutellars, shortened and thick at base, sharply tapered at tip. This bristle phenotype is stronger in homozygotes than heterozygotes. Homozygous viable.

      (Ives, 1940)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (95)
      Notes on Origin
      Discoverer

      Ives, 9th Jan. 1939.

      (Ives, 1940)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pin1
      (Sass and Ostrow, 2014)
      βTub60DPin-1
      Name Synonyms
      Secondary FlyBase IDs
        References (4)