FlyBase Allele Report: Dmel\Pc[5]

General Information

Symbol

Dmel\Pc⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0013555

Feature type

allele

Associated gene

Dmel\Pc

Associated Insertion(s)

Carried in Construct

Also Known As

Pc^T3

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tiong and Russell, 1990)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Tiong and Russell, 1990)

Phenotype Manifest In

mesothoracic leg

(Tiong and Russell, 1990)

wing

(Tiong and Russell, 1990)

Detailed Description

Statement

Reference

Homozygous Pc⁵ adults have a strong Pc adult phenotype, with transformations of 2nd leg to 1st leg, wing to haltere, ventral wing margin to dorsal wing margin, and posterior wing to anterior wing. Pc²²/Pc⁵ transheterozygotes are viable, with a weak incompletely penetrant Pc adult phenotype.

(Tiong and Russell, 1990)

homozygous viable? partial transformations of second and third legs into first legs when homozygous.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁴ has visible | dominant | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁴ has visible | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰³ has visible | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰² has visible | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁰ has visible | homeotic phenotype

(Boivin et al., 1999)

Df(1)ph-601, Pc⁵, ph-d⁴⁰¹ has visible | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰³ has visible | dominant | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰² has visible | dominant | homeotic phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁰ has visible | dominant | homeotic phenotype

(Boivin et al., 1999)

Df(1)ph-601, Pc⁵ has visible | dominant | homeotic phenotype

(Boivin et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pc⁵ has phenotype, enhanceable by Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Other

Statement

Reference

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁴ has wing | posterior phenotype

(Boivin et al., 1999)

Df(1)ph-601, Pc⁵, ph-d⁴⁰¹ has wing | posterior phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰³ has wing | posterior phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰² has wing | posterior phenotype

(Boivin et al., 1999)

Pc⁵, ph-d⁴⁰¹, ph-p⁶⁰⁰ has wing | posterior phenotype

(Boivin et al., 1999)

Df(1)ph-601, Pc⁵ has wing | posterior phenotype

(Boivin et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

ph-p⁶⁰² ph-d⁴⁰¹; Pc⁵/+ flies show a weak wing to haltere transformation. ph-p⁶⁰⁴ ph-d⁴⁰¹; Pc⁵/+ flies show a weak wing to haltere transformation. Df(1)ph-601; Pc⁵/+ flies show a weak wing to haltere transformation. ph-p⁶⁰⁰ ph-d⁴⁰¹; Pc⁵/+ flies show a weak wing to haltere transformation. ph-p⁶⁰³ ph-d⁴⁰¹; Pc⁵/+ flies show a weak wing to haltere transformation.

(Boivin et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Tiong.

Comments

Clonal analysis suggests that there is an early requirement for Pc activity in the determination of the 2nd leg, while it is required until differentiation in the wing disc.

(Tiong and Russell, 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pc⁵

Pc^T3

(Mollaaghababa et al., 2001, Boivin et al., 1999, Tiong and Russell, 1990)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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