FlyBase Allele Report: Dmel\otu[3]

General Information

Symbol

Dmel\otu³

Species

D. melanogaster

Name

FlyBase ID

FBal0013350

Feature type

allele

Associated gene

Dmel\otu

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Staab et al., 1996)

Mutagen

ethyl methanesulfonate

(Storto and King, 1987, King et al., 1986)

Progenitor genotype

Cytology

Description

sequenced by Steinhauer and Kalfayan, 1992

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | female

(Tirronen et al., 1993)

female sterile

(Bae et al., 1994)

female sterile | recessive

(Bopp et al., 1993, King et al., 1986)

female sterile germline-dependent | recessive

(Wieschaus et al., 1981)

Phenotype Manifest In

nurse cell

(Wieschaus et al., 1981)

oocyte

(Wieschaus et al., 1981)

ovariole

(Pauli et al., 1993, Storto and King, 1987, King et al., 1986)

ovary

(Bae et al., 1994, Bopp et al., 1993, Steinhauer and Kalfayan, 1992, Wieschaus et al., 1981)

Detailed Description

Statement

Reference

Tumorous phenotype.

(Rodesch et al., 1995)

Tumorous ovaries.

(Bae et al., 1994)

Tumorous ovarian cysts.

(Bopp et al., 1993)

Spermatogenesis normal but mating behaviour fails because wild type females refuse to react to the courtship attempts of mutant males. Effect is not absolute, and depends on allele (there is a strong correlation between male sterility and severity of impairment in the female phenotype) and varies between affecting 6.7% (otu¹⁴) and 86.6% (otu¹²) of mutant males.

(Tirronen et al., 1993)

Homozygous females have tumorous ovaries, hemizygous females have quiescent ovaries.

(Steinhauer and Kalfayan, 1992)

69% of homozygous ovarioles have tumorous oogonia, and 17.5% produce nurse cell/oocyte syncytia. otu¹¹/otu³ female flies are poorly fertile.

(Storto and King, 1987)

Oncogenic allele; over half of homozygous ovarioles contain tumour-generating oogonia, substantial numbers of differentiated cystocytes are also produced. 84% of hemizygous ovarioles are quiescent, while the remaining ovarioles are tumorous.

(King et al., 1986)

Ovaries of homozygous females are small and most of the oocytes are in previtellogenic stages. The few in advanced stages have abnormal nurse cells with large condensed nuclei.

(Wieschaus et al., 1981)

oncogenic; cystocytes continue dividing and produce tumors

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

otu³ is partially rescued by otu^hs.PN

(Rodesch et al., 1995)

Comments

One or two copies of P{hs-otu.N} causes substantial morphological suppression but only partial suppression of sterility.

(Rodesch et al., 1995)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Gans.

Comments

Germ line clonal analysis shows that otu function is required in the germ line.

(Wieschaus et al., 1981)

Oncogenic (ONC) class allele. The ovarian phenotype of flies transheterozygous for otu³ and a number of other otu mutations has been analysed.

(Storto and King, 1987)

Oncogenic class (ONC) of otu allele.

(Steinhauer and Kalfayan, 1992)

Tumorous cysts of homozygous females have readily detectable levels of protein, but the distribution of that protein is abnormal: small undifferentiated germ cells that populate the mutant ovary have cytoplasmic Sxl protein.

(Bopp et al., 1993)

Shows a dominant interaction with ovo^D2 and ovo^D3 : more extreme mutant phenotype as assayed by reduction in number of egg chambers at stage 10 or further developed. There is no apparent correlation with strength of otu allele and its interaction with the ovo alleles.

(Pauli et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

fs(1)116

(Wieschaus et al., 1981)

fs(1)A116

fs(1)G116

fs116

(King and Riley, 1982)

otu³

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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