FB2024_03 , released June 25, 2024
Allele: Dmel\Nfa-1
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General Information
Symbol
Dmel\Nfa-1
Species
D. melanogaster
Name
FlyBase ID
FBal0012863
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
opus{}Nfa-1
Carried in Construct
Also Known As
fa, facet
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Grimwade et al., 1985)
Progenitor genotype
Associated Insertion(s)
opus{}Nfa-1
Cytology
Description

Insertion transposable element opus into the second intron.

(Gorman and Girton, 1992)

Insertion of a copia-like element at coordinate -11kb (coordinates according to FBrf0045027 and FBrf0039003).

(Kelley et al., 1987)

Insert stated as cause: middle repetitive DNA (inserted between coordinates -8.4 and -10.9, zero coordinate is defined as the centre of the 2.2kb EcoRI fragment that encompasses the N76b8 inversion breakpoint).

(Grimwade et al., 1985)

opus at -11.9 to -11.2

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Slightly rough eyes.

      (Gorman and Girton, 1992)

      Retina defects are associated with optic lobe defects in 81.8% of homozygous Nfa-1 retina clones generated by somatic recombination. The arrangement of ommatidia is abnormal in homozygous clones in the retina. A disruption of the fenestrated zone and laminar cortex, and a few small vacuoles in the lamina neuropil can be seen in the underlying optic lobe if it is defective.

      (Markopoulou and Artavanis-Tsakonas, 1991)

      Homozygotes exhibit rough eyes.

      (Rabinow and Birchler, 1990)

      At 29oC, the eyes are rough and splotchy in homozygous females and there is a low penetrance of apical nicks in the wing. At 25oC eye roughness is weaker, and at 18oC the eyes are almost normal.

      (Shellenbarger and Mohler, 1975)

      Expression of the mutant phenotype is mild and variable.

      (Welshons, 1974)

      N47i/Nfa-1 flies show no phenotypic effect. N51d in combination with Nfa-1 shows a characteristic phenotype.

      (Meyer, 1952)

      Homozygotes have rough eyes.

      (Lewis, 1945)

      Nfa-1/Df(1)N-8 flies show disarrangement of the ommatidia, while it is comparatively rare that the posterior wing margin shows any notching. Nnd-0/Nfa-1 is phenotypically normal, except in very rare cases (0.26%) where slight notches in the wing are seen.

      (Glass, 1933)

      Eyes of all males moderately rough owing to irregularity in size, shape and arrangement of facets. Not dosage compensated; eyes of females less rough than those of males with about 10% overlap of wild type. Eye roughness of the females varies from nearly normal at 18oC to marked at 29oC; pupal stage temperature-sensitive (Shellenbarger and Mohler, 1975). Eye abnormality caused by overgrowth of secondary pigment cells, which compresses cones and causes overlying corneal facets to bulge (Waddington and Pilkington, 1942). Wings have apical nicks in 0.25% of males and 0-5% of females. N/Nfa-1 has rough eyes of Nfa-1 as well as a Notch phenotype weak allele temperature sensitive nicked wings not dosage compensated

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Nfa-1 has phenotype, non-enhanceable by E(S)1

      (Lewis, 1945)
      NOT suppressed by
      Statement
      Reference

      Nfa-1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Synergistic interactions with dx alleles.

      (Gorman and Girton, 1992)

      E(S)1 has little or no effect on the rough eye phenotype in ecunspecified E(S)1 double heterozygotes.

      (Lewis, 1945)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (1)
      Stocks (4)
      Notes on Origin
      Discoverer

      Bridges, Feb. 1914.

      Comments
      Comments

      Nfa-1 appears to act cell autonomously.

      (Markopoulou and Artavanis-Tsakonas, 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (23)