FB2024_03 , released June 25, 2024
Allele: Dmel\NCo
Open Close
General Information
Symbol
Dmel\NCo
Species
D. melanogaster
Name
Confluens
FlyBase ID
FBal0012759
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
Also Known As
Co
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Lyman and Young, 1993, Alton et al., 1989)
Mutagen
spontaneous
(Lyman and Young, 1993)
Progenitor genotype
Cytology
Description

In addition to the amino acid replacements, there is also a Q insertion between the Q amino acids at position 2567 and 2568.

(Lyman and Young, 1993)

Amino acid replacement: T1561S.

(Lyman and Young, 1993)

Amino acid replacement: S2257G.

(Lyman and Young, 1993)

Amino acid replacement: Q1865term.

(Lyman and Young, 1993)

Point mutation.

(Alton et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
X:3,170,492..3,170,493 [+]
Inserted_sequence:

CAR

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Mutation is an insertion of three base pairs encoding a glutamine between Q2567 and Q2568. One of two mutations in this strain.

(Lyman and Young, 1993)
point_mutation
X:3,168,221..3,168,221 [+]
Nucleotide change:

C3168221T

Amino acid change:

Q1865term | N-PA; Q1865term | N-PB

Reported amino acid change:

Q1865term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of two mutations in this strain.

(Lyman and Young, 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutant somatic clones in the eye, almost completely lack R8 cells or other neurons.

      (Li and Baker, 2001)

      NCo mutants exhibit thickened wing veins with deltas.

      NCo mutants exhibit elevated levels of asymmetry and reduced mean character size relative to Canton-S flies for thoracic bristles.

      NCo mutants show significantly reduced mean character size for orbital bristles compared to Canton-S flies.

      (Indrasamy et al., 2000)

      Homozygous clones in the wing disc disrupt the dorsal/ventral boundary.

      (Micchelli and Blair, 1999)

      Homozygous mutant clones in the wing disc fail to respect the dorsal ventral boundary.

      (Rauskolb et al., 1999)

      Thickened vein mutant.

      (Sturtevant and Bier, 1995)

      Strong neurogenic phenotype: overproduction of adult thoracic bristles. Heterozygotes have thickened wing veins that expand to form deltas at the junction of the wing tip and overproduce thoracic microchaetae. The presence of NCo enhances the phenotype of hypomorphic and null alleles of Dl.

      (Lyman and Young, 1993)

      Semilethal when heterozygous with Nnd-3.

      (Welshons, 1974)

      N68j/NCo flies are almost wild-type.

      (Hayman and Maddern, 1969)

      Wing tips seldom notched; veins thickened, with deltas. Acrostichal rows irregular. NCo/Nnd-3 heterozygotes lethal; rare survivors sterile and weak. NCo/+ females show thickened wing veins (a Confluens-like phenotype) more frequently than nicked or notched wings. Also, NCo heterozygous females with an extra dose of 3C6-7 <up>Dp(1;1)Co or Dp(1;2)51b</up> or hemizygous males with Dp(1;2)51b have an enhanced Confluens-like wing phenotype.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      NCo has visible phenotype, suppressible by su(N)1

      (California Institute of Technology, 1940)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      NCo has wing vein L2 phenotype, suppressible by su(N)1

      (California Institute of Technology, 1940)

      NCo has crossvein phenotype, suppressible by su(N)1

      (California Institute of Technology, 1940)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Phenotype is suppressed by su(N)1; NCo/su(N)1 flies have only slight thickening of wing vein L2, occasional thickening of the crossveins, but no deltas. NCo su(N)1 double homozygotes are almost completely wild type.

      (California Institute of Technology, 1940)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Welshons, 1955.

      Comments
      Comments

      A N phenotype can also result from duplication of N+, e.g. Dp(1;1)Co. Relation to N illustrated by three T(1;Y)'s with breakpoints in 3C: T(1;Y)D7, T(1;Y)R38 and T(1;Y)W17. The segmental duplication formed from T(1;Y)D7 and T(1;Y)R38 is Confluens in phenotype; the corresponding deficiency is normal. The segmental deficiency formed from T(1;Y)R38 and T(1;Y)W17 is N in phenotype and the corresponding duplication is normal. In addition to T(1;Y)R38, two other translocations appear to separate Dp(1;1)Co and N : T(1;Y)R30 and T(1;Y)J100 (Merriam and colleagues).

      Mapped by genetic recombination to between NAx-9 and Nnd-2.

      (Lyman and Young, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      References (26)