FB2024_03 , released June 25, 2024
Allele: Dmel\mysts2
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General Information
Symbol
Dmel\mysts2
Species
D. melanogaster
Name
FlyBase ID
FBal0012692
Feature type
allele
Associated gene
Dmel\mys
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

heat sensitive hypomorphic allele - genetic evidence

(Bunch et al., 1992)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: G347D.

(Jannuzi et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:8,067,285..8,067,285 [+]
Nucleotide change:

G8067285A

Amino acid change:

G347D | mys-PA; G347D | mys-PB; G347D | mys-PC; G347D | mys-PD

Reported amino acid change:

G347D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Jannuzi et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mysts2/+ heterozygotes are more sensitive to ethanol-induced sedation than wild type flies.

      (Ojelade et al., 2015)

      Homozygous and mysts2/mys8 flies show normal odour avoidance behaviour.

      (Bhandari et al., 2006)

      Weak allele.

      (Jannuzi et al., 2004)

      Lethality occurs during the embryonic/larval stages.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      mysts2 has chemical sensitive | adult stage phenotype, suppressible by icsG4/icsG4

      (Ojelade et al., 2015)
      NOT Suppressor of
      Statement
      Reference

      mysts2/mys[+] is a non-suppressor of chemical resistant | adult stage phenotype of icsG4

      (Ojelade et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mysts2/+;icsG4/icsG4 flies have the same increased resistance to ethanol-induced sedation seen in icsG4/icsG4 mutants alone, unlike ethanol-sensitive mysts2/+ flies.

      (Ojelade et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      mys11

      (Bunch et al., 1992)

      mys10

      (Bunch et al., 1992)

      mysxR04

      (Bunch et al., 1992)

      mysXN101

      (Bunch et al., 1992)
      Comments

      Complements mys10, mysXN101, mysxR04, mys11 and mys1 better at low than at high temperatures.

      (Bunch et al., 1992)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Wright.

      Comments
      Comments

      Restrictive temperature at 28-30oC.

      (Bunch et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mysts2
      (Ojelade et al., 2015, Pilgram et al., 2011, Bhandari et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)