FlyBase Allele Report: Dmel\mam[1]

General Information

Symbol

Dmel\mam¹

Species

D. melanogaster

Name

FlyBase ID

FBal0012009

Feature type

allele

Associated gene

Dmel\mam

Associated Insertion(s)

Carried in Construct

Also Known As

mam^N2G

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

spontaneous

natural population

P-element activity

(Weigel et al., 1987)

Progenitor genotype

Caused by aberration

In(2R)G

Cytology

Description

breakpoint near -27 kb

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Yedvobnick et al., 2004)

Phenotype Manifest In

embryonic/larval cuticle

(Schmid et al., 1996)

larval RP2 motor neuron | ectopic

(Yedvobnick et al., 2004)

presumptive embryonic/larval central nervous system

(Schmid et al., 1996)

RP2sib neuron

(Yedvobnick et al., 2004)

wing

(Helms et al., 1999)

Detailed Description

Statement

Reference

Mutant embryos have a strong neurogenic phenotype and also a show loss of asymmetry phenotype with GMC-1 of the RP2/sib lineage dividing symmetrically into two RP2 neurons.

(Yedvobnick et al., 2004)

The macrochaetae multiplication phenotype seen in mam^H.Scer\UAS,Scer\GAL4³⁰⁹ flies is enhanced by the addition of mam¹. Heterozygotes show an incompletely penetrant weak wing nicking phenotype. In combination with mam^H.Scer\UAS driven by Scer\GAL4^C96 an enhanced wing nicking phenotype is seen, also incompletely penetrant.

(Helms et al., 1999)

Embryonic CNS exhibits severe disturbances and larval exhibit moderate cuticle loss.

(Schmid et al., 1996)

terminal notching of the wing margins of heterozygotes; penetrance 100% N-2G considered an allele based on its failure to complement other mam alleles and on the embryonic phenotype of such non-complementing trans heterozygotes.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mam¹/mam[+] is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^bbg-C96, mam¹ has wing margin phenotype, suppressible by emc^D

(Kwon et al., 2013)

Enhancer of

Statement

Reference

mam¹/mam[+] is an enhancer of wing margin phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The wing nicking phenotype caused by expression of dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 is enhanced if the flies are also carrying mam¹/+.

(Kwon et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Ives. 17th Dec. 1941.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

N-2G

mam¹

mam^N-2G

(Weigel et al., 1987)

mam^N2G

(Kwon et al., 2013, Yedvobnick et al., 2004, Helms et al., 1999, Schmid et al., 1996, Rhyu et al., 1994, de Celis et al., 1993, Yedvobnick et al., 1988)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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