FlyBase Allele Report: Dmel\CycE[k05007]

(Murphy, 2003, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Spradling et al., 1999, Roote, 1995.5.4, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Ashburner et al., 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die before end of larval stage

(Murphy, 2003)

some die during larval stage

(Murphy, 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Most CNS cells in CycE^k05007 larvae are arrested in G1 phase.

(Murphy, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

CycE[+]/CycE^k05007 is an enhancer of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Enhancer of

Statement

Reference

CycE^k05007 is a non-enhancer of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

CycE[+]/CycE^k05007 is a non-enhancer of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

NOT Suppressor of

Statement

Reference

CycE[+]/CycE^k05007 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

CycE^k05007 is a non-suppressor of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

CycE[+]/CycE^k05007 is a non-suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

CycE[+]/CycE^k05007 is an enhancer of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Enhancer of

Statement

Reference

CycE^k05007 is a non-enhancer of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

CycE[+]/CycE^k05007 is a non-enhancer of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

NOT Suppressor of

Statement

Reference

CycE[+]/CycE^k05007 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

CycE^k05007 is a non-suppressor of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

CycE[+]/CycE^k05007 is a non-suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

CycE^k05007 is a non-suppressor of centrosome | increased number phenotype of SkpA¹

(Murphy, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of CycE^k05007 does not suppress the apoptosis seen in flies overexpressing hid

(Ambegaokar and Jackson, 2011)

A greater proportion of CycE^k05007; skpA¹ double mutant cells are arrested in G1 phase compared to CycE^k05007 single mutants. The CycE^k05007; skpA¹ double mutants show the same supernumerary centrosome phenotype as the skpA¹ single mutants.

(Murphy, 2003)

Xenogenetic Interactions

Statement

Reference

One copy of CycE^k05007 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of CycE^k05007 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Complements

CycE^k05002a

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Kyoto

108853

y¹ w^67c23; P{lacW}CycE^k05007/CyO

114333

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{lacW}CycE^k05007 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(Roote, 1995.5.4)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CycE^50/7

CycE^K05007

(Ambegaokar and Jackson, 2011)

CycE^k05007

k05007

(Mukherjee et al., 2006)

l(2)k05007

(Murphy, 2003, Spradling et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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