FB2024_03 , released June 25, 2024
Allele: Dmel\tkv04415
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General Information
Symbol
Dmel\tkv04415
Species
D. melanogaster
Name
FlyBase ID
FBal0008058
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
P{PZ}tkv04415
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(George and Terracol, 1997, Jiang and Struhl, 1996)
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}tkv04415
Cytology
Description

P{PZ} insertion at the 5' noncoding end of tkv-1 cDNA, at position 73 corresponding to the tkv-2 cDNA second intron.

(George and Terracol, 1997)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant clones show ectopic concentric folds in the leg disc epithelium, reflecting the formation of a secondary proximo-distal axis. Mutant cells positioned dorsally in the adult leg differentiate ectopic ventral structures such as sex comb teeth and organize the formation of supernumerary distal structures such as claws.

      (Jiang and Struhl, 1996)

      Germline clones produce eggs with patterning defects: embryos are ventralised.

      (Perrimon et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      tkv04415/tkv[+] is a non-enhancer of visible | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Suppressor of
      Statement
      Reference

      tkv04415/tkv[+] is a suppressor | partially of visible phenotype of I-2UAS.Tag:polyHis,Tag:MYC, Scer\GAL4vg.PM, putUAS.cMa

      (Bennett et al., 2003)
      NOT Suppressor of
      Statement
      Reference

      tkv04415/tkv[+] is a non-suppressor of visible | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      tkv04415/tkv[+] is a non-enhancer of eye | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Suppressor of
      Statement
      Reference

      tkv04415/tkv[+] is a suppressor | partially of wing phenotype of I-2UAS.Tag:polyHis,Tag:MYC, Scer\GAL4vg.PM, putUAS.cMa

      (Bennett et al., 2003)
      NOT Suppressor of
      Statement
      Reference

      tkv04415/tkv[+] is a non-suppressor of eye | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      tkvk16713

      (BDGP Project Members, 1994-1999)
      Rescued by

      tkv04415/tkv8 is rescued by tkvhs.PR

      (Jiang and Struhl, 1996)
      Comments

      Lethality of tkv04415/tkv8 can be rescued by tkvhs.PR.

      (Jiang and Struhl, 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      G. Campbell.

      (Jiang and Struhl, 1996)

      Separable from: Vha1604415. Evidence suggests that the "l(2)04415" line contains 2 P{PZ} insertions; one at 42C (P{PZ}Vha1604415) corresponding to the site of the flanking sequence AQ073280, and one at 25D (P{PZ}tkv04415) which causes a mutation in tkv.

      (FlyBase, 1996-)
      Comments
      Comments

      Complements: vkg01209. Complements: cype03771. Complements: l(2)0488404884. Complements: l(2)k01302k01302. Complements: vrik05901.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      l(2)04415
      (Spradling et al., 1999)
      l(2)0441504415
      (Jiang and Struhl, 1996)
      tkv04415
      (Ayyaz et al., 2015)
      tkv09415
      (Wilk et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)