FB2024_03 , released June 25, 2024
Allele: Dmel\br2Bab-1
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General Information
Symbol
Dmel\br2Bab-1
Species
D. melanogaster
Name
FlyBase ID
FBal0006652
Feature type
allele
Associated gene
Dmel\br
Associated Insertion(s)
Carried in Construct
Also Known As
l(1)t4
Key Links
Allele class

amorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Gotwals and Fristrom, 1991)

hypomorphic allele - genetic evidence

(Restifo and Merrill, 1994, Kiss et al., 1988)
Mutagen
ethyl methanesulfonate
(Restifo and Merrill, 1994, Gotwals and Fristrom, 1991, Kiss et al., 1988, Belyaeva et al., 1982)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Failure of salivary gland degeneration. Reduction in dorso-ventral class of indirect flight muscles.

      (Restifo and White, 1992)

      18--28% penetrance of zip interaction with br2Bab-1 heterozygous females.

      (Gotwals and Fristrom, 1991)

      92% incidence rate of SEG-TG separation failure.

      (Restifo and White, 1991)

      br2Bab-1/br2Bc-1 heterozygotes have malformations of the basitarsus on the third pair of legs. Lacks 'br', 'rbp' and 'l(1)2Bc' function.

      (Kiss et al., 1988)

      Puparium formation delayed by 6 hours. Pupae die without imaginal organs.

      (Belyaeva et al., 1982)

      Heterozygotes with alleles of br or 'rbp' have reduced number of bristles on the palpus and have short, broad wings. Heterozygotes with Df(1)br25 are completely lethal.

      (Belyaeva et al., 1980)

      br2Bab-1 pupae have normal imaginal organs and escapers have faded wings and reduced bristles on palpi. Prepupal lethal in combination with brnpr-1 or Df(1)S39. Puparium formation delayed six hours. Surviving br2Bab-1/brrbp-1 and br2Bab-1/br2Bc-1 exhibit malformed-leg syndrome.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      2Bab1
      (Liu and Restifo, 1998)
      br2Bab-1
      l(1)2Bab1
      l(1)t4
      (Solov'eva, 1992, Mazina et al., 1991, Mazina et al., 1990, Solovyeva and Belyaeva, 1989, Belyaeva et al., 1982)
      lt4
      (Restifo and Merrill, 1994)
      t4
      (Belyaeva et al., 1980)
      Name Synonyms
      Secondary FlyBase IDs
        References (14)