FB2024_03 , released June 25, 2024
Allele: Dmel\Kr9
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General Information
Symbol
Dmel\Kr9
Species
D. melanogaster
Name
FlyBase ID
FBal0005796
Feature type
allele
Associated gene
Dmel\Kr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Kraut and Levine, 1991, Warrior and Levine, 1990, Redemann et al., 1988)

loss of function allele

(Kraut and Levine, 1991)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987, Preiss et al., 1985)
Progenitor genotype
KrIf-1
(Preiss et al., 1985)
Cytology

Polytene chromosomes normal.

(Preiss et al., 1985)
Description

Amino acid replacement: C255S.

(Gaul et al., 1989)

Amino acid replacement: C255S. C255S maps to the second zinc finger.

(Jäckle et al., 1988)

Nucleotide substitution: T?A. Amino acid replacement: C255S. C255S maps to the second zinc finger.

(Redemann et al., 1988)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:25,228,087..25,228,087 [+]
Nucleotide change:

T25228087A

Reported nucleotide change:

A1135T

Amino acid change:

C255S | Kr-PA; C255S | Kr-PB

Reported amino acid change:

C255S

(Jäckle et al., 1988, Redemann et al., 1988)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ctLS enhancer trap lines in a Kr1 or Kr9 mutant background demonstrate that the Malpighian tubule cells are transformed into a structure consistent in appearance and cell number with a change in cell fate to a hindgut. ct expression in the Malpighian tubules is greatly reduced.

      (Liu and Jack, 1992)

      gt expression domains are extended towards the centre.

      (Kraut and Levine, 1991)

      Kr9 homozygous embryos show extensive deletions in the region between T1 and A5.

      (Kraut and Levine, 1991)

      Strong segmentation phenotype. Homozygous embryos do not differentiate Malpighian tubules. The hindgut is larger than wild-type.

      (Harbecke and Janning, 1989)

      Segments T1 through A5 are deleted and replaced with a mirror image duplication of segment A6 in homozygous embryos.

      (Jäckle et al., 1988)

      The thoracic and five abdominal segments are deleted, and replaced by a mirror image duplication of abdominal segment 6. The Malpighian tubules are missing.

      (Redemann et al., 1988)

      Strong allele. Segments T1 to T3, and A1 to A5 are deleted.

      (Preiss et al., 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Kr9 is a non-enhancer of lethal | embryonic stage | maternal effect phenotype of Gugunspecified

      (Zhang et al., 2002)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The expression of various gap and pair-rule genes in wild-type and Kr9 mutant embryos has been studied.

      (Warrior and Levine, 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      9
      (Skaer, 1993)
      Kr9
      (Campbell et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (17)