FlyBase Allele Report: Dmel\kni[3]

General Information

Symbol

Dmel\kni³

Species

D. melanogaster

Name

FlyBase ID

FBal0005773

Feature type

allele

Associated gene

Dmel\kni

Associated Insertion(s)

Carried in Construct

Also Known As

kni^14F

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Gerwin et al., 1994, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

245bp deletion from 3489 to 3733bp. This results in a frameshift, producing a protein with the N-terminal 232 amino acids of kni followed by an additional 105 amino acids.

(Gerwin et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:20,693,185..20,693,429 [-]

Comment:

Deletion of 245bp leads to a frameshift, producing a protein with the N-terminal 232 amino acids of kni followed by 105 novel amino acids.

(Gerwin et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Ruden and Jäckle, 1995)

some die during embryonic stage | recessive

(Ruden and Jäckle, 1995)

Phenotype Manifest In

abdomen

(Nauber et al., 1988)

Detailed Description

Statement

Reference

Homozygotes can be propagated as fertile stocks when on copy of Res is present. kni³/kni⁸ transheterozygotes are viable. kni³ Res¹ double homozygous mutants have a wild type abdominal segmentation phenotype, defective head skeleton and are embryonic lethal.

(Ruden and Jäckle, 1995)

Weak phenotype.

(Gerwin et al., 1994)

Homozygous embryos exhibit 3 abdominal segments.

(Nauber et al., 1988)

weak

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

kni³ has lethal phenotype, non-suppressible by Res^1r1

(Ruden and Jäckle, 1995)

kni³ has lethal phenotype, non-suppressible by Res^1r2

(Ruden and Jäckle, 1995)

kni³ has lethal phenotype, non-suppressible by Res^1r3

(Ruden and Jäckle, 1995)

Phenotype Manifest In

Suppressed by

Statement

Reference

kni³ has embryonic abdominal segment phenotype, suppressible by Res^1r1

(Ruden and Jäckle, 1995)

NOT suppressed by

Statement

Reference

kni³ has embryonic abdominal segment phenotype, non-suppressible by Res^1r2

(Ruden and Jäckle, 1995)

kni³ has embryonic abdominal segment phenotype, non-suppressible by Res^1r3

(Ruden and Jäckle, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

kni³ fails to complement kni^ri-1 when it is carried on a chromosome such as TM3 or In(3LR)LD6 that is rearranged with respect to the kni³ mutant chromosome. kni³ fully complements kni^ri-1 when the kni^ri-1 and kni³ alleles are carried on non-rearranged chromosomes.

(Lunde et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Intermediate kni allele.

(Ruden and Jäckle, 1995, Nauber et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

kni^14F

(Ruden and Jäckle, 1995, Gerwin et al., 1994, Lehmann, 1988, Nauber et al., 1988, Tearle and Nusslein-Volhard, 1987)

kni³

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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