FB2024_03 , released June 25, 2024
Allele: Dmel\kni1
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General Information
Symbol
Dmel\kni1
Species
D. melanogaster
Name
knirps1
FlyBase ID
FBal0005771
Feature type
allele
Associated gene
Dmel\kni
Associated Insertion(s)
Carried in Construct
Also Known As
kni5F107, kni5F
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Gerwin et al., 1994, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G3001A. Amino acid replacement: G70D.

(Gerwin et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:20,693,917..20,693,917 [-]
Nucleotide change:

G20693917A

Reported nucleotide change:

G3001A

Amino acid change:

G70D | kni-PA; G75D | kni-PB

Reported amino acid change:

G70D

(Gerwin et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      kni1/+ embryos display a high frequency of A4 loss.

      (Zhang et al., 2011)

      Intermediate phenotype.

      (Gerwin et al., 1994)

      No changes in phenotype of tor13D embryos.

      (Strecker et al., 1991)

      Abdominal segments missing.

      (Jack et al., 1988)

      Homozygous embryos exhibit 5 abdominal segments.

      (Nauber et al., 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      kni[+]/kni1 is an enhancer of embryonic/larval segmentation phenotype | maternal effect | recessive phenotype of Acsl1

      (Zhang et al., 2011)
      NOT Enhancer of
      Statement
      Reference

      kni1 is a non-enhancer of lethal | embryonic stage | maternal effect phenotype of Gugunspecified

      (Zhang et al., 2002)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      kni1/+ significantly increases the fraction of embryos showing segmentation defects caused by maternal mutant homozygous Acsl1. The segmentation abnormalities become more severe as indicated by more segments being disrupted in each mutant embryo.

      (Zhang et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      kni1 fails to complement kniri-1 when it is carried on a chromosome such as TM3 or In(3LR)LD6 that is rearranged with respect to the kni1 mutant chromosome. kni1 fully complements kniri-1 when the kniri-1 and kni1 alleles are carried on non-rearranged chromosomes.

      (Lunde et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weak kni allele.

      (Nauber et al., 1988)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (14)