FB2024_03 , released June 25, 2024
Allele: Dmel\hook1
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General Information
Symbol
Dmel\hook1
Species
D. melanogaster
Name
FlyBase ID
FBal0005492
Feature type
allele
Associated gene
Dmel\hook
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Kramer and Phistry, 1999)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G1964T, in a splice donor site. This results in a C-terminally truncated protein.

(Kramer and Phistry, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,031,820..19,031,820 [-]
Nucleotide change:

G19031820T

Comment:

Altered splice donor site; results in a 489aa polypeptide.

(Kramer and Phistry, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants have a glial overmigration phenotype in the eye disc.

      (Yuva-Aydemir et al., 2011)

      hk1/hk11 males have a shortened adult life span compared to controls, with a mean life span of 18.76 days at 25o.

      hk1 males have a shortened adult life span compared to controls, with a mean life span of 19.861 days at 25o.

      (Simonsen et al., 2007)

      Hemizygotes have a hooked-bristle phenotype. hk1/hk11 flies do not show any signs of eye degeneration.

      (Kramer and Phistry, 1999)

      Flies exhibit pleiotrophic phenotypes including abnormal bristle morphology (bristles often have a sharp bend and the tips are blunt instead of tapered) and light-dependent eye degeneration (degeneration is reduced but not completely suppressed in the dark).

      (Kramer and Phistry, 1996)

      Bristles nearly all hooked at tip or blunted, some bent at right angles. Scutellars and verticals especially affected. Acrostichal hairs fewer and outer rows separated. Eyes slightly roughened. Wings usually divergent and may be smaller. Body sometimes small and chunky. Less extreme expression at 19oC, especially the wing character, but classification reliable. RK2.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      hk[+]/hook1 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      hook1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Enhancer of
      Statement
      Reference

      hk[+]/hook1 is an enhancer of embryonic/larval cuticle phenotype of baz4

      (Shao et al., 2010)

      hk[+]/hook1 is an enhancer of embryonic/larval cuticle phenotype of bazG0484

      (Shao et al., 2010)

      hk[+]/hook1 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The cuticle phenotype of dead embryos derived from baz4/+ embryos derived from a cross of baz4/+ females to wild-type males is enhanced if the females also carry one copy of hk1.

      The cuticle phenotype of dead embryos derived from bazG0484/+ embryos derived from a cross of bazG0484/+ females to wild-type males is enhanced if the females also carry one copy of hk1.

      (Shao et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (1)
      Stocks (68)
      Notes on Origin
      Discoverer

      Mohr, 4th Jan. 1924.

      Comments
      Comments

      Homozygotes and hemizygotes show degeneration of the eye. This is probably due to a second site mutation on the hk1 chromosome, as hk1/hk11, hk11/Df(2L)TW130 flies and flies overexpressing hk1-551.GMR.T:Hsap\MYC do not show any sign of eye degeneration.

      (Kramer and Phistry, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      hk1
      hook1
      (Yuva-Aydemir et al., 2011)
      hook1
      (Simonsen et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)