FB2024_03 , released June 25, 2024
Allele: Dmel\hfw7
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General Information
Symbol
Dmel\hfw7
Species
D. melanogaster
Name
FlyBase ID
FBal0005460
Feature type
allele
Associated gene
Dmel\hfw
Associated Insertion(s)
Carried in Construct
Also Known As
swit467
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Belyaeva and Zhimulev, 1982)
Progenitor genotype
Cytology
Description

Amino acid replacement: C379Y. Nucleotide substitution: G1428762A. (Nucleotide coordinates refer to coordinates relative to Release 3.1 of the Drosophila melanogaster genome).

(Schwartz et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:1,671,990..1,671,990 [+]
Nucleotide change:

G1671990A

Reported nucleotide change:

G1428762A

Amino acid change:

C379Y | hfw-PA; C379Y | hfw-PB

Reported amino acid change:

C379Y

(Schwartz et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Some homozygotes exhibit the disturbance of puparium formation characteristic for hfw mutants.

      (Belyaeva and Zhimulev, 1982)

      About 2.5% homozygous larvae pupariate only in anterior part of the body ('half way'). Most individuals die when they are mature pupae.

      (Belyaeva et al., 1982)

      Some homozygous larvae exhibit puparium formation only on the anterior half of the body.

      (Belyaeva et al., 1980)

      No late larval or pupal puffs in polytene chromosomes of homozygotes (Belyaeva and Zhimulev, 1986). late prepupal lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      hfw7 is rescued by hfw+tSWI4

      (Schwartz et al., 2004)

      hfw7 is rescued by hfw+tSWI3

      (Schwartz et al., 2004)
      Not rescued by

      hfw7 is not rescued by hfwtSWI1

      (Schwartz et al., 2004)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Not rescued by: P{5581}.

      (Schwartz et al., 2004)

      In homozygotes intermoult early and early-late larval 20-OH ecdysone puffs do not differ from wild type. Late larval and prepupal puffs are reduced or absent.

      (Belyaeva and Zhimulev, 1982)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (8)