FB2024_03 , released June 25, 2024
Allele: Dmel\hb8
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General Information
Symbol
Dmel\hb8
Species
D. melanogaster
Name
FlyBase ID
FBal0005399
Feature type
allele
Associated gene
Dmel\hb
Associated Insertion(s)
Carried in Construct
Also Known As
hb9Q, hb9Q17
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Bonneton et al., 1997, Hulskamp et al., 1994, Tautz, 1988)
Mutagen
ethyl methanesulfonate
(Hulskamp et al., 1994, Lehmann and Nusslein-Volhard, 1987, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Mutation is before the first zinc finger domain.

(Hulskamp et al., 1994)

Nucleotide substitution: C?A.

(Hulskamp et al., 1994)

Amino acid replacement: Y215term.

(Hulskamp et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,693,510..8,693,510 [-]
Nucleotide change:

C8693510A

Reported nucleotide change:

C?A

Amino acid change:

Y215term | hb-PA; Y215term | hb-PB

Reported amino acid change:

Y215term

(Hulskamp et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In hb8 mutant embryos initial tracheal development appears normal up to stage 12. Subsequently the trunk branches become stalled and misrouted, whereas the other primary branches are formed as in wild-type embryos. Despite the strong dorsal trunk phenotype, the dorsal trunk branches occasionally fuse in mutant embryos and form dorsal trunk rudiments.

      (Wolf and Schuh, 2000)

      Mutant first instar larvae have abnormal mouth hooks, lack labial and thoracic segments and have a fusion of abdominal segments 7 and 8.

      (Bonneton et al., 1997)

      All thoracic segments and the most posterior gnathal segment are missing.

      (Hulskamp et al., 1994)

      Embryos derived from hb15 bcd6 females, and also zygotically mutant for hb8 show a mirror image duplication of abdominal segments, centered around A6, and segments A7 and A8 are fused.

      (Hulskamp et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      hb8 is a non-enhancer of lethal | embryonic stage | maternal effect phenotype of Gugunspecified

      (Zhang et al., 2002)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      hb8 has larval labial segment phenotype, suppressible by Mdoa\hbtBa

      (Bonneton et al., 1997)

      hb8 has larval prothoracic segment phenotype, suppressible by Mdoa\hbtBa

      (Bonneton et al., 1997)
      NOT suppressed by
      Statement
      Reference

      hb8 has larval mesothoracic segment phenotype, non-suppressible by Mdoa\hbtBa

      (Bonneton et al., 1997)

      hb8 has larval metathoracic segment phenotype, non-suppressible by Mdoa\hbtBa

      (Bonneton et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The hb8 phenotype is partially rescued by Mdoa\hbtBa; the labial segment and first thoracic segment are rescued, but not the other thoracic segments.

      (Bonneton et al., 1997)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Class I allele.

      Phenotypic class I.

      (Lehmann and Nusslein-Volhard, 1987)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (14)