FlyBase Allele Report: Dmel\ft[G]

General Information

Symbol

Dmel\ft^G

Species

D. melanogaster

Name

FlyBase ID

FBal0004804

Feature type

allele

Associated gene

Dmel\ft

Associated Insertion(s)

412{}ft^G

Carried in Construct

Also Known As

Gull

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Mahoney et al., 1991)

Mutagen

spontaneous

(Mahoney et al., 1991)

Progenitor genotype

Associated Insertion(s)

412{}ft^G

Cytology

Description

A complete 7kb 412 transposable element is inserted in the 33rd cadherin domain. The 412 transposon inserted into ft differs from previously described 412 insertions: the 5' LTR contains an additional 33bp of which 29 are a direct repeat of the LTR sequence, there is a 3bp insertion between ft and the 5' LTR, and 11bp of ft DNA at the site of insertion is lost.

(Mahoney et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:4,203,923..4,203,935 [-]

(Mahoney et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

hyperplasia | recessive

(Buratovich and Bryant, 1997)

lethal | recessive

(Mahoney et al., 1991)

lethal - all die during embryonic stage | recessive

(Bryant et al., 1988)

some die during embryonic stage | recessive

(Bryant et al., 1988)

visible | adult stage | dominant

(Bryant et al., 1988)

visible | dominant

(Buratovich and Bryant, 1997)

Phenotype Manifest In

imaginal disc

(Buratovich and Bryant, 1997)

wing

(Buratovich and Bryant, 1997, Bryant et al., 1988)

Detailed Description

Statement

Reference

ft^G has no rescuing effect on mxc^G48 or mxc^G43.

(Saget et al., 1998)

Heterozygotes show outstretched wings. Homozygotes show overgrowth of imaginal discs.

(Buratovich and Bryant, 1997)

Additional wild-type copies of the ft gene can suppress the characteristics of the ft^G phenotype.

(Mahoney et al., 1991)

Heterozygous adults have held out wings, and there are minor changes in bristle pattern on the head. Transheterozygous combinations of ft^G with ft^G-rv, ft⁸ or ft¹ produces larvae with overgrown discs that die at the pupal stage, with some exaggerated "fat" escapers in the case of ft¹.

(Bryant et al., 1988)

Wings large, held out from sides at 45-90^o angle, curved downward and somewhat pointed. Vein L1 thickened; crossveins closer together, sometimes broken. Thoracic and vertical bristles duplicated in majority of flies. G/ft has exaggerated ft phenotype. Partially inhibited by ds/+ and much inhibited by ds/ds. Homozygous lethal. RK2. Causes local shortening of map by about 1.1 units.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ft^G, l(2)gd1¹ has hyperplasia | recessive phenotype

(Buratovich and Bryant, 1997)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

ft^G is a non-suppressor of phenotype of mxc^G43

(Saget et al., 1998)

ft^G is a non-suppressor of phenotype of mxc^G48

(Saget et al., 1998)

Other

Statement

Reference

ft^G, l(2)gd1¹ has eye-antennal disc phenotype

(Buratovich and Bryant, 1997)

ft^G, l(2)gd1¹ has wing disc phenotype

(Buratovich and Bryant, 1997)

ft^G, l(2)gd1¹ has imaginal disc phenotype

(Buratovich and Bryant, 1997)

ft^G, l(2)gd1¹ has leg disc phenotype

(Buratovich and Bryant, 1997)

ft^G, l(2)gd1¹ has haltere disc phenotype

(Buratovich and Bryant, 1997)

ft^G, l(2)gd1¹ has genital disc phenotype

(Buratovich and Bryant, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Clones double mutant for l(2)gd1¹ and ft^G show extensive overgrowth. Wing discs bend at the hinge region and show many extra folds that probably result from excess proliferation. Discs are initially smaller than wild type or either single mutant but eventually outgrow them. Leg discs are greatly overgrown, approximating the size of a wild type wing disc, and show no sign of duplications, except for the first leg disc. Haltere disc is also overgrown with an occasional duplication of the capitellum pouch. The eye-antennal disc is massively overgrown and becomes the largest disc, with duplications and triplications of the antenna knob and the retinal field. Genital discs duplicate and show many extra folds. Double mutants do not survive to pharate adults.

(Buratovich and Bryant, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

286

ds¹ S¹ ft^G b¹ pr¹/In(2L)Cy, In(2R)Cy, al² Duox^Cy lt³ L⁴ speck²

Kyoto

105834

ds¹ S¹ ft^G b¹ pr¹/In(2L)Cy, In(2R)Cy, al² Duox^Cy lt³ L⁴ speck²

Notes on Origin

Discoverer

Mohr, 23rd Nov. 1919.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ft^G

l(2)ft^G

(Buratovich and Bryant, 1997)

Name Synonyms

Gull

(Saget et al., 1998, Woods and Bryant, 1992, Mahoney et al., 1991, Bryant et al., 1988)

Secondary FlyBase IDs

References (9)

Report Sections

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