FlyBase Allele Report: Dmel\ft[15]

General Information

Symbol

Dmel\ft¹⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0004801

Feature type

allele

Associated gene

Dmel\ft

Associated Insertion(s)

Carried in Construct

Also Known As

ft^sz44

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Contains a 31 bp deletion and a 14bp insertion in the 32nd cadherin domain. The consequence of these alterations is to produce a truncated form of the fat protein.

(Mahoney et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2L:4,204,126..4,204,158 [-]

Comment:

A 31 bp deletion and a 14 bp insertion leads to a frameshift and early translation termination.

(Mahoney et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity | cell non-autonomous | somatic clone

(Casal et al., 2002)

abnormal planar polarity (with ft¹²)

(Repiso et al., 2010)

lethal | recessive

(Mahoney et al., 1991)

lethal - all die during embryonic stage | recessive

(Bryant et al., 1988)

some die during embryonic stage | recessive

(Bryant et al., 1988)

Phenotype Manifest In

adult cuticle | cell non-autonomous | somatic clone

(Casal et al., 2002)

macrochaeta | cell non-autonomous | somatic clone

(Casal et al., 2002)

microchaeta | cell non-autonomous | somatic clone

(Casal et al., 2002)

tergite | cell non-autonomous | somatic clone

(Casal et al., 2002)

ventral denticle belt (with ft¹²)

(Repiso et al., 2010)

Detailed Description

Statement

Reference

ft¹⁵/ft¹² mutants exhibit largely depolarized denticle belts.

(Repiso et al., 2010)

In the anterior compartments of the tergites, ft¹⁵ somatic clones tend to disturb and reverse polarity behind the clone, while, in the posterior compartments, they tend to reverse in front. However, when anterior ft¹⁵ clones abut the compartment boundary they fail to reverse the polarity of posterior compartment cells behind. Similarly, when posterior ft¹⁵ clones abut the compartment boundary they fail to reverse the polarity of anterior compartment cells in front.

(Casal et al., 2002)

ft¹⁵/ft⁸ transheterozygotes die at the pupal stage, and the larvae have overgrown imaginal discs.

(Bryant et al., 1988)

embryonic lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^αTub84B.PL, ds^UAO71, ft¹⁵, ft^UAS.cMa has abnormal planar polarity | cell non-autonomous | somatic clone phenotype, enhanceable | somatic clone by fj^UAS.cZa/Scer\GAL4^αTub84B.PL

(Brittle et al., 2010)

ft¹²/ft¹⁵ has abnormal planar polarity phenotype, enhanceable by ds^UAO71

(Repiso et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^αTub84B.PL, ds^UAO71, ds^ecto.UAS, ft¹⁵ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, suppressible | somatic clone by fj^UAS.cZa/Scer\GAL4^αTub84B.PL

(Brittle et al., 2010)

Enhancer of

Statement

Reference

ft¹⁵ is an enhancer of abnormal planar polarity phenotype of ds^UAO71

(Repiso et al., 2010)

Other

Statement

Reference

Scer\GAL4^αTub84B.PL, ds^UAO71, ft¹⁵, ft^UAS.cMa has abnormal planar polarity | somatic clone | cell non-autonomous phenotype

(Brittle et al., 2010)

Scer\GAL4^αTub84B.PL, ds^UAO71, ds^ecto.UAS, ft¹⁵ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype

(Brittle et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^αTub84B.PL, ds^UAO71, ft¹⁵, ft^UAS.cMa has trichome & tergite | cell non-autonomous | somatic clone phenotype, enhanceable | somatic clone by fj^UAS.cZa/Scer\GAL4^αTub84B.PL

(Brittle et al., 2010)

ft¹²/ft¹⁵ has ventral denticle belt phenotype, enhanceable by ds^UAO71

(Repiso et al., 2010)

ft¹²/ft¹⁵ has denticle row 5 phenotype, enhanceable by ds^UAO71

(Repiso et al., 2010)

ft¹²/ft¹⁵ has denticle row 6 phenotype, enhanceable by ds^UAO71

(Repiso et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^αTub84B.PL, ds^UAO71, ds^ecto.UAS, ft¹⁵ has trichome & tergite | cell non-autonomous | somatic clone phenotype, suppressible | somatic clone by fj^UAS.cZa/Scer\GAL4^αTub84B.PL

(Brittle et al., 2010)

Enhancer of

Statement

Reference

ft¹⁵ is an enhancer of ventral denticle belt phenotype of ds^UAO71

(Repiso et al., 2010)

ft¹⁵ is an enhancer of denticle row 5 phenotype of ds^UAO71

(Repiso et al., 2010)

ft¹⁵ is an enhancer of denticle row 6 phenotype of ds^UAO71

(Repiso et al., 2010)

Other

Statement

Reference

Scer\GAL4^αTub84B.PL, ds^UAO71, ft¹⁵, ft^UAS.cMa has trichome & tergite | somatic clone | cell non-autonomous phenotype

(Brittle et al., 2010)

Scer\GAL4^αTub84B.PL, ds^UAO71, ds^ecto.UAS, ft¹⁵ has trichome & tergite | somatic clone | cell non-autonomous phenotype

(Brittle et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

ds^UAO71 ft¹⁵ double mutant clones in the dorsal adult abdomen where the clones are also expressing ds^{ecto.Scer\UAS} under the control of Scer\GAL4^αTub84B.PL strongly repolarise hairs behind the clone, reversing their polarity (100% of clones repolarise with a maximum range of up to seven cells). This repolarisation is largely suppressed by co-expression of fj^Scer\UAS.cZa within the clone (48% of clones show some repolarisation with a range of one to three cells).

ds^UAO71 ft¹⁵ double mutant clones in the dorsal adult abdomen where the clones are also expressing ft^Scer\UAS.cMa under the control of Scer\GAL4^αTub84B.PL cause repolarisation in front of the clones, so that hairs point away from the clone (64% of clones repolarise with a maximum range of seven cells). Co-expression of fj^Scer\UAS.cZa within these clones strengthens the repolarisation (95% of clones repolarise with a maximum range of seven cells).

(Brittle et al., 2010)

ds^UAO71 ft¹⁵ double mutants exhibit largely depolarized denticle belts (with rows 5 and 6 more disturbed than in ds^UAO71 mutants). In addition to the orientation defects, the rows partially lose their distinctive characteristics.

(Repiso et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ft¹⁵

(Saavedra et al., 2016, Vrabioiu and Struhl, 2015, Brittle et al., 2010, Repiso et al., 2010, Casal et al., 2006)

ft^sz44

(Mahoney et al., 1991, Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)sz44

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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