FB2024_03 , released June 25, 2024
Allele: Dmel\fliI3
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General Information
Symbol
Dmel\fliI3
Species
D. melanogaster
Name
FlyBase ID
FBal0004037
Feature type
allele
Associated gene
Dmel\fliI
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Miklos and de Couet, 1990)
Progenitor genotype
Cytology
Description

Amino acid replacement: G601S.

(de Couet et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:21,341,857..21,341,857 [+]
Nucleotide change:

G21341857A

Reported nucleotide change:

G?A

Amino acid change:

G601S | fliI-PA

Reported amino acid change:

G601S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(de Couet et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  obesity
      CEA with fliI14
      (Park et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fliI3/fliI4 adults have irregular indirect flight muscles. The myofibrils of the indirect flight muscles are irregular.

      (Schnorrer et al., 2010)

      The muscles of fliI3 mutants show severely disrupted Z-bands and peripheral fraying of the myofibrils.

      (Gajewski et al., 2006)

      Flight ability is restored by introduction of a construct carrying a wild type copy of fliI.

      (Campbell et al., 1993)

      Indirect flight muscles fibres have disorganised Z-bands, and show fraying of the thick and thin filaments at the periphery of the fibres. Hemizygotes have normal viability but are flightless. fliI3/fliI14 and fliI3/fliI21 flies are flightless.

      (Miklos and de Couet, 1990)

      Homozygous viable. Homozygous germline clones display no maternal effect. Embryos derived from heterozygous mothers have CNS and PNS defects.

      (Perrimon et al., 1989)

      Homozygotes are flightless.

      (Homyk and Emerson, 1988)

      nonconditional

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      fliI3; CanB2EP774 flies show a strong suppression of the indirect flight muscle collapse phenotype of CanB2EP774 single mutants. The majority of the DLM fail to collapse in the double mutants; all double mutants have at least 7 DLMs present, with some mutants exhibiting as many as 12 DLMs. However, these DLMs have smaller fibers than in wild type and often exhibit holes in the cytoplasm.

      (Gajewski et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Homyk.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (14)