FlyBase Allele Report: Dmel\f[5]

General Information

Symbol

Dmel\f⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0003947

Feature type

allele

Associated gene

Dmel\f

Associated Insertion(s)

gypsy{}f-1

gypsy{}f-5

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Hoover et al., 1993)

Progenitor genotype

f¹

(Hoover et al., 1993, Ishimaru and Saigo, 1993)

Associated Insertion(s)

gypsy{}f-1

gypsy{}f-5

Cytology

Description

Insertion of a full length gypsy element within the 3' untranslated region for all f transcripts in the same orientation as the f gene.

(Hoover et al., 1993)

Includes a total of two gypsy inserts, one in the second intron and the second in the 3' flanking sequences.

(Ishimaru and Saigo, 1993)

A member of the right hand group of alleles; contains two gypsy inserts, one which is similar or identical to that of f¹ and the other which is closer to the SalI restriction site (1.2 kb); orientation is the same. In addition f⁵ contains a 4.4 kb insert in a restriction fragment to the left of that carrying the f¹ gypsy insert; it is located approximately 4.7 kb to the left of the reference SalI site (McLachlan, 1986).

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Dickinson and Thatcher, 1997)

Phenotype Manifest In

macrochaeta

(Hoover et al., 1993)

microchaeta

(Hoover et al., 1993)

ventral denticle belt

(Dickinson and Thatcher, 1997)

Detailed Description

Statement

Reference

Larvae exhibit an intermediate bristle phenotype within the denticles of all rows.

(Dickinson and Thatcher, 1997)

Strong f bristle phenotype. Bristle phenotype is under the control of a second site modifier.

(Hoover et al., 1993)

strong - macrochaetae and microchaetae strongly gnarled suppressed by su(f) suppressed by su(Hw)² RK1

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

f⁵ has phenotype, suppressible by e(w^e)¹

(Rutledge et al., 1988)

Additional Comments

Genetic Interactions

Statement

Reference

f¹ su(f)²/f⁵ su(f)¹ females show suppression of the f mutant phenotype similar to that seen in f¹ su(f)¹/f⁵ su(f)¹ females at 24-25^oC. At 20-30^oC, the f¹ su(f)²/f⁵ su(f)¹ combination shows suppression of the f mutant phenotype but bristles are Minute-like.