FlyBase Allele Report: Dmel\dpp[s8]

General Information

Symbol

Dmel\dpp^s8

Species

D. melanogaster

Name

FlyBase ID

FBal0003078

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Segal and Gelbart, 1985)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(St. Johnston et al., 1990, Segal and Gelbart, 1985)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Segal and Gelbart, 1985)

visible | dominant

(Segal and Gelbart, 1985)

Phenotype Manifest In

wing vein L2 | distal

(de Celis, 1997)

wing vein L4 | distal

(de Celis, 1997)

wing vein L5 | distal

(de Celis, 1997)

Detailed Description

Statement

Reference

dpp^s4/dpp^s8 flies lack the distal ends of wing vein LII, LIV and LV.

(de Celis, 1997)

A posterior clone runs along the antero-posterior boundary until it reaches a gap in wing vein 4 (a region sensitive to lack of dpp) where the border of the clone becomes irregular.

(Hidalgo, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

FoxK⁴⁴, dpp[+]/dpp^s8 has lethal phenotype

(Casas-Tinto et al., 2008)

FoxK¹⁶, dpp[+]/dpp^s8 has lethal phenotype

(Casas-Tinto et al., 2008)

dpp^s8, nub¹ has visible phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^s8, nub² has visible phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12/dpp^s8, nub¹ has visible phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12/dpp^s8, nub² has visible phenotype

(Cifuentes and Garcia-Bellido, 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^s4/dpp^s8 has wing vein phenotype, enhanceable by tkv¹/tkv⁸

(de Celis, 1997)

Suppressor of

Statement

Reference

dpp^s4/dpp^s8 is a suppressor of phenotype of tkv¹/tkv⁸

(de Celis, 1997)

dpp^s4/dpp^s8 is a suppressor of wing vein | ectopic phenotype of Ras64B^Act5C.PC

(de Celis, 1997)

dpp^s4/dpp^s8 is a suppressor of wing vein | ectopic phenotype of rho^hs.PSt

(de Celis, 1997)

Other

Statement

Reference

dpp^s8, nub¹ has wing phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^s8, nub² has wing phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12/dpp^s8, nub¹ has wing phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12/dpp^s8, nub² has wing phenotype

(Cifuentes and Garcia-Bellido, 1997)

N^Ax-1, dpp^s4/dpp^s8 has wing vein phenotype

(de Celis, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Double heterozygous dpp^s8; fd68A⁴⁴ mutants exhibit almost 100% viability.

Double heterozygous dpp^s8; fd68A¹⁶ mutants exhibit almost 100% viability.

(Casas-Tinto et al., 2008)

Double mutant clones with nub¹ or nub² cause dramatic reduction of cell number in the wing pouch.

(Cifuentes and Garcia-Bellido, 1997)

The dpp shortvein phenotype is strongly enhanced, and the tkv phenotype is suppressed, in dpp^s4 tkv¹/dpp^s8 tkv⁸ double mutant flies. The rho^hs.PSt and Ras64B^Act5C.PC ectopic vein phenotypes are suppressed in combination with dpp^s4/dpp^s8. dpp^s4/dpp^s8 N^Ax-1 double mutant flies show pronounced wing vein loss. The dpp loss of vein phenotype is epistatic in dpp^s4/dpp^s8 N^nd-3 double mutants, and the vein thickening characteristic of N^nd-3 is eliminated.

(de Celis, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Allele class: shv-lnc

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

98357

dpp^s8/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dpp^S8

(Cifuentes and Garcia-Bellido, 1997)

dpp^s8

(Casas-Tinto et al., 2008)

shv^S8

(Segal and Gelbart, 1985)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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