FB2024_03 , released June 25, 2024
Allele: Dmel\dpyov1
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General Information
Symbol
Dmel\dpyov1
Species
D. melanogaster
Name
oblique vortex
FlyBase ID
FBal0002834
Feature type
allele
Associated gene
Dmel\dpy
Associated Insertion(s)
blood{}dpyov1
Carried in Construct
Also Known As
dpov1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Associated Insertion(s)
blood{}dpyov1
Cytology
Description

Insertion of a blood element into intron 11.

(Carmon et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dpyov1 mutants exhibit epidermal invaginations or elevations on the notum at the muscle insertion sites of DLM (comma phenotype), as well as a oblique wing.

      (Chu and Hayashi, 2021)

      dpyov1 homozygotes show a small, oblique wing phenotype.

      (Kandasamy et al., 2021)

      dpyov1 mutant wing blades exhibit collapse of the distal tip: the 'dumpy' phenotype.

      dpyo2/dpyov1 mutant wing blades exhibit complete retraction of the wing blade: the 'truncate' phenotype.

      (Ray et al., 2015)

      Mutant flies show significantly increased survival compared to wild-type flies after infection with E. chaffeensis. Bacterial replication is significantly reduced in the mutant flies compared to wild type.

      (Von Ohlen et al., 2012)

      Mutant flies have anterior indentations in the notum epidermis.

      (Olguín et al., 2011)

      "ov" class allele.

      (Carmon et al., 2010)

      dpov1 embryos do not show defects in tracheal tube length and do not show breaks in the tracheal branches.

      (Swanson et al., 2009)

      dpTC4/dpov1 flies have "lopped" and "vortex" phenotypes. Body and leg size are reduced.

      (Carlson, 1956)

      Oblique wing phenotype (o). Thoracic vortex phenotype (v). Wings reduced one-third and have oblique truncation; angle between veins L2 and L3 widened; intercrossvein distances shortened; marginal vein intact; two vortices with whorls of hairs in dorsocentral region; dorsocentral bristles medially displaced; vortex expression in most flies at 26oC; comma effect in anterior thorax also present in most flies at 26oC. At lower temperatures, wing effect persists, but thorax appears normal. Body and leg size normal except at temperatures above 28oC, when they are somewhat reduced. RK1.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      dpyov1 has visible | adult stage phenotype, enhanceable by qsmF17fs/qsmF17fs

      (Chu and Hayashi, 2021)

      dpyov1 has abnormal planar polarity phenotype, enhanceable by chas1

      (Olguín et al., 2011)

      dpyov1 has visible phenotype, enhanceable by chas1

      (Olguín et al., 2011)
      Enhancer of
      Statement
      Reference

      dpyov1 is an enhancer of visible | adult stage phenotype of qsmF17fs

      (Chu and Hayashi, 2021)

      dpyov1 is an enhancer of abnormal planar polarity phenotype of chas1

      (Olguín et al., 2011)

      dpyov1 is an enhancer of visible phenotype of chas1

      (Olguín et al., 2011)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      dpyov1 has wing phenotype, enhanceable by qsmF17fs/qsmF17fs

      (Chu and Hayashi, 2021)

      dpyov1 has thoracic tergum phenotype, enhanceable by qsmF17fs/qsmF17fs

      (Chu and Hayashi, 2021)

      dpyov1 has mesothoracic tergum phenotype, enhanceable by chas1

      (Olguín et al., 2011)
      Suppressed by
      Statement
      Reference

      dpyov1/dpyo2 has wing phenotype, suppressible by su(dpyov)2

      (Kjaer, 1989)

      dpyov1/dpyo2 has wing phenotype, suppressible by su(dpyov)3

      (Kjaer, 1989)

      dpyov1 has wing phenotype, suppressible by su(dpyov)1

      (Kjaer, 1989)

      dpyov1 has adult thorax phenotype, suppressible by su(dpyov)1

      (Kjaer, 1989)

      dpyov1 has wing phenotype, suppressible by su(dpyov)2

      (Kjaer, 1989)

      dpyov1 has wing phenotype, suppressible by su(dpyov)3

      (Kjaer, 1989)

      dpyov1/dpyo2 has wing phenotype, suppressible by su(dpyov)1

      (Kjaer, 1989)
      NOT suppressed by
      Statement
      Reference

      dpyv2/dpyov1 has adult thorax phenotype, non-suppressible by su(dpyov)1

      (Kjaer, 1989)

      dpyv2/dpyov1 has adult thorax phenotype, non-suppressible by su(dpyov)2

      (Kjaer, 1989)

      dpyv2/dpyov1 has adult thorax phenotype, non-suppressible by su(dpyov)3

      (Kjaer, 1989)

      dpyov1 has adult thorax phenotype, non-suppressible by su(dpyov)2

      (Kjaer, 1989)

      dpyov1 has adult thorax phenotype, non-suppressible by su(dpyov)3

      (Kjaer, 1989)
      Enhancer of
      Statement
      Reference

      dpyov1 is an enhancer of wing phenotype of qsmF17fs

      (Chu and Hayashi, 2021)

      dpyov1 is an enhancer of thoracic tergum phenotype of qsmF17fs

      (Chu and Hayashi, 2021)

      dpyov1 is an enhancer of mesothoracic tergum phenotype of chas1

      (Olguín et al., 2011)

      dpyov1 is an enhancer of presumptive embryonic/larval tracheal system phenotype of varif00033

      (Swanson et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      chas1 dpov1 double mutants show enhanced indentations of the anterior notum epidermis and enhanced planar polarity defects compared to either single mutant.

      (Olguín et al., 2011)

      The tracheal tube length defects caused by varif00033 are enhanced if the embryos are also mutant for dpov1.

      (Swanson et al., 2009)

      The oblique wing phenotype is suppressed in homozygous su(dpov)1, su(dpov)2 or su(dpov)3 flies. The vortex (thoracic invagination) phenotype is suppressed in homozygous su(dpov)1 flies. The wing phenotype of dpov1/dpo2 flies is totally suppressed by su(dpov)1, su(dpov)2 or su(dpov)3.

      (Kjaer, 1989)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (2)
      Stocks (166)
      Notes on Origin
      Discoverer

      Morgan, 16 Oct. 1918.

      Comments
      Comments

      Aspartate transcarbamylase (ATCase), orotate phosphoribosyltransferase (OPRTase) and orotidine-5'-phosphate decarboxylase (ODCase) activity is elevated in dpov1 flies and normalised in su(dpov)1 dpov1 flies.

      (Kjaer, 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      References (22)