FlyBase Allele Report: Dmel\dlg1[12]

General Information

Symbol

Dmel\dlg1¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0002681

Feature type

allele

Associated gene

Dmel\dlg1

Associated Insertion(s)

Carried in Construct

Also Known As

dlg^m30

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

Mutagen

ethyl nitrosourea

(Woods and Bryant, 1989)

Progenitor genotype

Cytology

Description

Missense mutation in the SH3 domain.

(Siegrist and Doe, 2005)

Point mutation, substitution of a highly conserved Leu to Pro in the SH3 domain, without altering the PDZ or GUK domains.

(Tejedor et al., 1997)

Nucleotide substitution: T1895C. Amino acid replacement: L632P. Mutation is in the SH3 domain.

(Woods et al., 1996)

Disrupts the SH3 domain.

(Lahey et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,398,481..11,398,481 [+]

Nucleotide change:

T11398481C

Reported nucleotide change:

T1895C

Amino acid change:

Reported amino acid change:

L632P

(Woods et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

bouton

(Lahey et al., 1994)

imaginal disc

(Woods et al., 1996)

Detailed Description

Statement

Reference

Mutants develop large neoplastic tumours and die at the beginning of metamorphosis.

(Tejedor et al., 1997)

Homozygous larvae exhibit overgrown imaginal discs. Salivary gland cells show no obvious morphological or ultrastructural defects.

(Woods et al., 1996)

Lethality occurs during metamorphosis with neoplastic growth in imaginal discs and CNS. The morphology of the synaptic bouton structure is altered and the subsynaptic reticulum (SSR) is substantially less extensive and less complex than in wild type.

(Lahey et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

dlg1¹⁸

(Woods et al., 1996)

dlg1⁷

(Woods et al., 1996)

dlg1⁶

(Woods et al., 1996)

Fails to complement

dlg1¹⁵

(Woods et al., 1996)

dlg1¹⁴

(Woods et al., 1996)

Rescued by

dlg1¹² is rescued by Scer\GAL4^32B/dlg1^UAS.cBa

(Woods et al., 1996)

Comments

Scer\GAL4^32B mediated expression of dlg1^Scer\UAS.cBa rescues lethality to adulthood.

(Woods et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

94707

y¹ w^* dlg1¹²/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

Notes on Origin

Discoverer

Voelker.

Comments

Class II mutation.

(Woods et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Dlg^m30

(Tian et al., 2023)

dlg1¹²

dlg^m30

(Khoury and Bilder, 2022, Khoury and Bilder, 2020, Kim et al., 2016, Siegrist and Doe, 2005, Bachmann et al., 2004, Mendoza et al., 2003, Caruana, 2002, Bellaiche et al., 2001, Thomas et al., 2000, Tejedor et al., 1997, Woods et al., 1996, Lahey et al., 1994)

l(1)M30

l(1)d.lg-1^m30

(Gateff and Mechler, 1989)

m30

(Woods and Bryant, 1989)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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