FlyBase Allele Report: Dmel\Nrt[M2]

General Information

Symbol

Dmel\Nrt^M2

Species

D. melanogaster

Name

FlyBase ID

FBal0002234

Feature type

allele

Associated gene

Dmel\Nrt

Associated Insertion(s)

Carried in Construct

Also Known As

dab^M2

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Liebl et al., 2003, Gertler et al., 1989)

Progenitor genotype

Cytology

Description

Nucleotide substitution: T?A.

(Liebl et al., 2003)

Amino acid replacement: L464term.

(Liebl et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,775,210..16,775,210 [+]

Nucleotide change:

T16775210A

Reported nucleotide change:

T?A

Amino acid change:

L464term | Nrt-PA; L464term | Nrt-PB; L464term | Nrt-PC

Reported amino acid change:

L464term

(Liebl et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Bennett and Hoffmann, 1992)

some die during embryonic stage | recessive

(Bennett and Hoffmann, 1992)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Abl¹/Df(3L)st-j7, Nrt^M2 has lethal phenotype, suppressible | partially by Scer\GAL4³¹/Abl^UAS.cFa

(Fogerty et al., 1999)

Abl¹/Df(3L)st-j7, Nrt^M2 has lethal phenotype, suppressible | partially by Scer\GAL4³¹/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS

(Fogerty et al., 1999)

Abl¹/Df(3L)st-j7, Nrt^M2 has lethal phenotype, suppressible | partially by Scer\GAL4³¹/Abl::Hsap\ABL1::Hsap\BCR^P185.UAS

(Fogerty et al., 1999)

Abl¹/Df(3L)st-j7, Nrt^M2 has lethal phenotype, suppressible | partially by Scer\GAL4³¹/Abl^K417N.UAS

(Fogerty et al., 1999)

Enhancer of

Statement

Reference

Nrt^M2 is an enhancer of lethal phenotype of Abl¹

(Gertler et al., 1989)

Nrt^M2 is an enhancer of lethal phenotype of Abl²

(Gertler et al., 1989)

Other

Statement

Reference

Abl¹/Df(3L)st-j7, Nrt^M54/Nrt^M2 has abnormal neuroanatomy phenotype

(Liebl et al., 2003)

Abl¹/Df(3L)st-j7, Nrt^M2 has lethal phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P185.UAS, Abl¹/Df(3L)st-j7, Nrt^M2, Scer\GAL4³¹ has visible phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹/Df(3L)st-j7, Nrt^M2, Scer\GAL4³¹ has visible phenotype

(Fogerty et al., 1999)

Phenotype Manifest In

Other

Statement

Reference

Abl¹/Df(3L)st-j7, Nrt^M54/Nrt^M2 has larval ventral nerve cord commissure phenotype

(Liebl et al., 2003)

Abl::Hsap\ABL1::Hsap\BCR^P185.UAS, Abl¹/Df(3L)st-j7, Nrt^M2, Scer\GAL4³¹ has eye phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P185.UAS, Abl¹/Df(3L)st-j7, Nrt^M2, Scer\GAL4³¹ has ommatidium phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹/Df(3L)st-j7, Nrt^M2, Scer\GAL4³¹ has eye phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹/Df(3L)st-j7, Nrt^M2, Scer\GAL4³¹ has ommatidium phenotype

(Fogerty et al., 1999)

Abl¹/Df(3L)st-j7, Nrt^M2 has symmetrical commissure phenotype

(Gertler et al., 1993)

Abl¹/Df(3L)st-j7, Nrt^M2 has axon phenotype

(Gertler et al., 1993)

Additional Comments

Genetic Interactions

Statement

Reference

63% of segments have commissure defects in the central nervous system of Abl¹ Nrt^M54/Nrt^M2 Df(3L)st-j7 embryos.

(Liebl et al., 2003)

The lethality of Abl¹/Nrt^M2 Df(3L)st-j7 is partially rescued by Abl^Scer\UAS.cFa or Abl^{K417N.Scer\UAS}, expressed under the control of Scer\GAL4³¹.

(Fogerty et al., 1999)

fax^M7 Abl¹/In(3L)std11 and fax^M12 Abl¹/In(3L)std11 individuals are lethal due to disruptions in the CNS longitudinal and commissural axons. The presence of Nrt^M2 does not affect the lethality. Dosage sensitive interactions exist between Nrt^M2, fax^M7 and fax^M12. Abl^+mTnabl is unable to rescue the lethality of fax^- Nrt^- individuals.

(Hill et al., 1995)

Abl¹/Df(3L)st-j7 Nrt^M2 double mutant causes absence of most intersegmental longitudinal axon bundles and most commissural axon bundles. The lethality of Nrt^M2 Df(3L)st-j7/Abl¹ animals is rescued by four copies of P{Dab.G} to almost full viability.

(Gertler et al., 1993)

Nrt^M2 Df(3L)st-j7/In(3L)std11 double mutant embryos show muscle absences and detachments.

(Bennett and Hoffmann, 1992)

Enhances the Abl¹ and Abl² mutant phenotype from pupal lethal to embryonic or larval lethality by an haploinsufficiency dependent on Abl (HDA).

(Gertler et al., 1989)

Xenogenetic Interactions

Statement

Reference

The lethality of Abl¹/Nrt^M2 Df(3L)st-j7 is partially rescued by Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} or Abl::Hsap\ABL1::Hsap\BCR^{P185.Scer\UAS} expressed under the control of Scer\GAL4³¹.

(Fogerty et al., 1999)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced on: Df(3L)st-j7. The Nrt^M2 mutant allele was originally thought to be a mutation in the Dab gene (see FBrf0058531 and FBrf0084025), but sequencing of the chromosome indicates that it is a lesion in the Nrt gene.

(Liebl et al., 2003)

Induced on: Df(3L)st-j7.

(Gertler et al., 1989)

Comments

Complements: l(3)73Bc^unspecified.

(Gertler et al., 1989)

Haploinsufficiency dependent upon an Abl mutant background (HDA).

(Hill et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Dab¹

Dab^m2

(Gertler et al., 1993)

(Gertler et al., 1989)

Nrt^M2

dab^M2

(Liebl et al., 2003, Gertler et al., 1989)

dab^m2

(Fogerty et al., 1999, Hill et al., 1995, Bennett and Hoffmann, 1992, Belote et al., 1990)

nrt^M2

(Liebl et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (7)

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