FB2024_03 , released June 25, 2024
Allele: Dmel\da5
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General Information
Symbol
Dmel\da5
Species
D. melanogaster
Name
FlyBase ID
FBal0002218
Feature type
allele
Associated gene
Dmel\da
Associated Insertion(s)
Carried in Construct
Also Known As
daIIB31, daII134
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Gonzalez-Crespo and Levine, 1993)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: Y111term.

(Baker and Cronmiller, 2001)

Nucleotide substitution: T559A.

(Baker and Cronmiller, 2001)

normal Southern

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:10,390,394..10,390,394 [+]
Nucleotide change:

T10390394A

Reported nucleotide change:

T559A

Amino acid change:

Y111term | da-PA; Y111term | da-PB; Y111term | da-PC; Y111term | da-PD

Reported amino acid change:

Y111term

(Baker and Cronmiller, 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In homozygous da5 embryos, mesoderm differentiation is affected. Visceral muscle develops normally and losses in pericardial and cardial cells are detected in a low percentage of embryos. In contrast, somatic muscles show greater defects that are detectable in every embryo, but vary from segment to segment. Duplications and losses of somatic muscle are seen. The addition of da5/+ to twiScer\UAS.cBa, Scer\GAL4twi.PB embryos enhances the losses in gut and heart forming mesoderm. Two copies can also enhance the ectopic muscle phenotype as well. Muscle VT1 is absent in some abdominal segments.

      (Castanon et al., 2001)

      Homozygous clonal tissue within the eye causes a narrow anterior-posterior scar. Larger clones in the anterior of the eye are observed, in the centre of the clone several mutant ommatidia surround an area lacking photoreceptor cells.

      (Brown et al., 1996)

      Homozygous embryos have noticeable thinning in areas along the ventral nerve cord.

      (Kovalick and Beckingham, 1992)

      Lethal; lethal with da1, Df or other lethal alleles.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      da5 is an enhancer of visible | dominant phenotype of E(spl)m8-HLH1, Nspl-1

      (Nagel and Preiss, 1999)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (13)