FB2024_03 , released June 25, 2024
Allele: Dmel\ctn
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General Information
Symbol
Dmel\ctn
Species
D. melanogaster
Name
notch
FlyBase ID
FBal0002094
Feature type
allele
Associated gene
Dmel\ct
Associated Insertion(s)
roo{}ctn
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
heat
(Johnson and Judd, 1979, Plough and Ives, 1934)
Progenitor genotype
Associated Insertion(s)
roo{}ctn
Cytology

Polytene chromosomes normal.

(Johnson and Judd, 1979)
Description

Insertion of roo element.

(Georgiev and Gerasimova, 1989)

Insertion of roo.

(Tchurikov et al., 1989)

roo insertion DNA coordinates (FBrf0042060) (0 is gypsy site in ct6): -6.8 to -4.8

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ctn homozygotes do not show significant mortality during the pharate stage.

      (Guida et al., 2016)

      ctn wings have a notched edge.

      (Matsui et al., 2011)

      Severe allele that produces extensive loss of wing margin structures.

      (de Celis and Bray, 1997)

      Adult wing margin has gaps at the tip.

      (Jack et al., 1991)

      Phenotype is unaffected by mod(mdg4)ul.

      (Georgiev and Gerasimova, 1989)

      Notched wings. Completely complemented by Df(1)R19.

      (Johnson and Judd, 1979)

      Phenotype is much less extreme than ct1. Shallow terminal notches are seen between wing veins L2 and L3 and between veins L3 and L4. Some variation in the phenotype is seen. ctn/ct1 flies have the same phenotype as ctn homozygotes.

      (Plough and Ives, 1934)

      cut wings Wings notched at tips. Classification of males reliable, of females harder, but perfect at higher temperatures. Viability excellent. RK1 in male.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      ctn/ctn is a non-enhancer of increased mortality | pharate adult stage phenotype of lncRNA:flam1

      (Guida et al., 2016)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      ctn has wing margin phenotype, non-suppressible by ToporsZ4522/nbl[+]

      (Matsui et al., 2011)

      ctn has wing margin phenotype, non-suppressible by ToporsZ1837/nbl[+]

      (Matsui et al., 2011)

      ctn has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The pharate mortality of flam1 homozygotes is not significantly increased by ctn homozygozity.

      (Guida et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (4)
      Notes on Origin
      Discoverer

      Ives, 3rd March 1932.

      Ives

      (Plough and Ives, 1934)
      Comments
      Comments

      Phenotype showed no interaction with mw2.

      (Rabinow and Birchler, 1990)

      Weak ct allele.

      (Jack et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ct32c3
      (Plough and Ives, 1934)
      ctn
      (Guida et al., 2016, King et al., 2014, Matsui et al., 2011, Brandt and Corces, 2008)
      Name Synonyms
      notch
      Secondary FlyBase IDs
        References (20)