FlyBase Allele Report: Dmel\ct[6]

General Information

Symbol

Dmel\ct⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0001934

Feature type

allele

Associated gene

Dmel\ct

Associated Insertion(s)

gypsy{}ct⁶

Carried in Construct

Also Known As

cut⁶

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Johnson and Judd, 1979)

Progenitor genotype

Associated Insertion(s)

gypsy{}ct⁶

Cytology

Polytene chromosomes normal.

(Johnson and Judd, 1979)

Description

Insertion of a gypsy element between the ct promoter and a distal wing-margin enhancer.

(Cai and Levine, 1997)

gypsy insertion into the ct locus control region.

(Morcillo et al., 1996)

gypsy insertion maps to the region between the wing margin enhancer and the block of embryonic ct enhancers.

(Dorsett, 1993)

Insertion of gypsy element at nucleotide position -118.

(Tchurikov et al., 1989)

DNA coordinates (FBrf0042060) = 0

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult head

(Morcillo et al., 1996)

chemosensory ventral triple row bristle

(Ludlow et al., 1996)

dorsal row of double row of wing sensilla

(Ludlow et al., 1996)

dorsal-ventral compartment boundary of the wing disc | third instar larval stage

(Becam et al., 2011)

mechanosensory ventral triple row bristle

(Ludlow et al., 1996)

medial row of triple row of wing sensilla

(Ludlow et al., 1996)

vibrissal bristle

(Dorsett, 1993, Johnson and Judd, 1979)

wing

(Ramos et al., 2011, Mongelard et al., 2002, Bezborodova et al., 1997, Cai and Levine, 1997, Ludlow et al., 1996, Melnikova et al., 1996, Morcillo et al., 1996, Dorsett, 1993, Georgiev and Gerasimova, 1989, Johnson and Judd, 1979)

wing (with ct^A)

(Guida et al., 2016)

wing & macrochaeta | posterior

(Ludlow et al., 1996)

wing | precursor

(Fristrom, 1969, Waddington, 1940, Waddington, 1939)

wing blade

(Krupp et al., 2005)

wing margin

(Matsui et al., 2011, Oliver et al., 2010, Golovnin et al., 2008, Capelson and Corces, 2006, Capelson and Corces, 2005)

wing margin bristle

(Krupp et al., 2005)

Detailed Description

Statement

Reference

ct⁶ homozygotes do not show significant mortality during the pharate stage.

ct^A/ct⁶ transheterozygotes exhibit a cut-wing phenotype, as compared to controls

(Guida et al., 2016)

ct⁶/+ wings are similar to wild type.

(Aparicio et al., 2015)

ct⁶ mutant late third instar wing discs have disturbed dorsal-ventral (DV) boundaries compared to controls. The anterior-posterior boundary is unaffected.

(Becam et al., 2011)

ct⁶ wings have a notched edge.

(Matsui et al., 2011)

ct⁶ mutants show wing margin defects.

(Oliver et al., 2010)

ct⁶ mutant animals develop "cut" wings, missing regions of the wing margin.

(Golovnin et al., 2008)

ct⁶ mutants exhibit a jagged or cut appearance of the fly wing edge.

(Capelson and Corces, 2006)

Hemizygotes show a reduction in the numbers of wing margin bristles and and incised wing margin and wing blade.

(Krupp et al., 2005)

Severe cuts in the wing margin.

(Mongelard et al., 2002)

Shows no interaction with pb mutations.

(Johnston et al., 1998)

Homozygotes lack wing margin tissue in distal and posterior regions of the wing.

(Cai and Levine, 1997)

ct⁶ is strongly suppressed by mod(mdg4)^ul : only 20% of flies have one to five gaps in the wing margin. Strong and weak su(Hw) mutations, with or without mod(mdg4)^ul, completely suppress the ct⁶ phenotype. su(Hw)^J and su(Hw)^Δ100 slightly suppress the phenotype of ct⁶ unless in combination with mod(mdg4)^ul, when the phenotype is completely suppressed.

(Georgiev and Kozycina, 1996)

The ct⁶ phenotype is not suppressed in flies carrying su(Hw)^wt or su(Hw)^Δ656-705 in a su(Hw)⁷/su(Hw)^V background, slightly suppressed in flies carrying su(Hw)^Δ706-736 or su(Hw)^Δ881-944 in a su(Hw)⁷/su(Hw)^V background, and strongly or completely suppressed in flies carrying su(Hw)^Δ673-943, su(Hw)^{Δ2-203.673-943}, su(Hw)^Δ738-780, su(Hw)^Δ2-203, su(Hw)^Δ853-880 or su(Hw)^Δ782-944 in a su(Hw)⁷/su(Hw)^V background.

(Kim et al., 1996)

Scalloped wing margin and lack of many sensory bristles at the anterior wing margin. All non-innervated hairs of the posterior wing margin are absent.

(Ludlow et al., 1996)

Homozygotes display cut wing and head capsule defects.

(Morcillo et al., 1996)

ct wing and vibrissae phenotype.

(Dorsett, 1993)

Geotaxis score significantly lower than for Canton S in a Hirsch-type geotaxis maze.

(McMillan and McGuire, 1992)

No embryonic phenotype.

(Blochlinger et al., 1990)

When in combination with sc alleles ct⁶ exhibited excisions and hair reduction on the external edge of the wing.

(Georgiev, 1990)

Wings are cut to points, and the wing margins are scalloped.

(Georgiev and Gerasimova, 1989)

Phenotype is not affected by Doa^HD or Doa⁶.

(Rabinow and Birchler, 1989)

Scalloped wings. Vibrissae are missing. Completely complemented by Df(1)R19.

(Johnson and Judd, 1979)

Cell death observed in prepupal wing bud.

(Fristrom, 1969)

Wing bud narrower than wild type as early as just after eversion of wing in early pupa.

(Waddington, 1940, Waddington, 1939)

Cut wing character uniform and reliable; usually lacks the abdomen, antenna, arista, and eye effects of ct. Vibrissae gone or displaced downward to bottom of eye. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ct⁶, mod(mdg4)^ul has visible | adult stage phenotype, enhanceable by shep^d05714

(Chen et al., 2019)

ct⁶, mod(mdg4)^ul has visible | adult stage phenotype, enhanceable by T7\RpT7^{UAS.Tag:NLS(SV40-largeT)}/Scer\GAL4^Ser.PU/su(Hw)^T7.Tag:MYC

(Matzat et al., 2013)

ct⁶, mod(mdg4)^ul has visible | adult stage phenotype, enhanceable by T7\RpT7^{UAS.Tag:NLS(SV40-largeT)}/Cp190^T7.Tag:MYC/Scer\GAL4^Ser.PU

(Matzat et al., 2013)

Suppressed by

Statement

Reference

ct⁶, y² has visible | adult stage phenotype, suppressible by HIPP1^UAS.mCh/Scer\GAL4^vg.PM

(Stow et al., 2022)

ct⁶, mod(mdg4)^ul, shep^d05714 has increased mortality during development phenotype, suppressible | partially by Scer\GAL4^Ser.PGF/shep^UAS.E

(Chen et al., 2019)

ct⁶, mod(mdg4)^ul, shep^d05714 has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^Ser.PGF/shep^UAS.E

(Chen et al., 2019)

ct⁶, mod(mdg4)^T6 has visible phenotype, suppressible by Cp190^En15

(Oliver et al., 2010)

ct⁶ has visible phenotype, suppressible by Cp190^En15/Cp190^P11

(Oliver et al., 2010)

ct⁶ has visible phenotype, suppressible by mod(mdg4)^ul

(Golovnin et al., 2008, Capelson and Corces, 2005, Bezborodova et al., 1997, Cai and Levine, 1997, Georgiev and Gerasimova, 1989)

ct⁶ has visible phenotype, suppressible by mod(mdg4)^T6

(Golovnin et al., 2008)

ct⁶ has visible phenotype, suppressible by Scer\GAL4^bbg-C96/BacA\p35^UAS.cHa

(Krupp et al., 2005)

ct⁶ has visible | recessive phenotype, suppressible by mod(mdg4)^T6

(Mongelard et al., 2002)

ct⁶ has visible | recessive phenotype, suppressible by mod(mdg4)^ul

(Mongelard et al., 2002)

ct⁶, mod(mdg4)^ul has visible | recessive phenotype, suppressible by Su(mg)1-7^1-7

(Bezborodova et al., 1997)

ct^L32/ct⁶ has visible phenotype, suppressible by su(Hw)^e2

(Morcillo et al., 1996)

NOT suppressed by

Statement

Reference

ct⁶, y² has visible | adult stage phenotype, non-suppressible by HIPP1^ΔCLD31.2/HIPP1^ΔCLD14.3

(Stow et al., 2022)

ct⁶, mod(mdg4)^ul, shep^d05714 has increased mortality during development phenotype, non-suppressible by shep^RRM.UAS.E/Scer\GAL4^Ser.PGF

(Chen et al., 2019)

ct⁶, mod(mdg4)^ul, shep^d05714 has majority die during pupal stage phenotype, non-suppressible by shep^RRM.UAS.E/Scer\GAL4^Ser.PGF

(Chen et al., 2019)

ct⁶, mod(mdg4)^ul, shep^d05714 has visible | adult stage phenotype, non-suppressible by shep^RRM.UAS.E/Scer\GAL4^Ser.PGF

(Chen et al., 2019)

ct⁶ has visible | recessive phenotype, non-suppressible by mod(mdg4)^neo129/mod(mdg4)^ul

(Mongelard et al., 2002)

ct⁶ has visible | recessive phenotype, non-suppressible by mod(mdg4)^UASp.cMa/Scer\GAL4^Act5C.PI/mod(mdg4)^ul

(Mongelard et al., 2002)

ct⁶ has visible | recessive phenotype, non-suppressible by mod(mdg4)^L3101/mod(mdg4)^ul

(Mongelard et al., 2002)

Enhancer of

Statement

Reference

ct⁶/ct⁶ is an enhancer of increased mortality | pharate adult stage phenotype of lncRNA:flam¹

(Guida et al., 2016)

Other

Statement

Reference

ct⁶, y² has visible | adult stage phenotype

(Stow et al., 2022)

ct⁶, mod(mdg4)^ul, shep^d05714 has partially lethal - majority die phenotype

(Chen et al., 2019)

ct⁶, mod(mdg4)^ul, shep^d05714 has majority die during pupal stage phenotype

(Chen et al., 2019)

Scer\GAL4^Ser.PGF, ct⁶, mod(mdg4)^ul, shep^UAS.E, shep^d05714 has partially lethal - majority live phenotype

(Chen et al., 2019)

Scer\GAL4^Ser.PGF, ct⁶, mod(mdg4)^ul, shep^UAS.E, shep^d05714 has some die during pupal stage phenotype

(Chen et al., 2019)

ct⁶, mod(mdg4)^ul has viable phenotype

(Chen et al., 2019)

ct⁶, mod(mdg4)^ul has visible | adult stage phenotype

(Chen et al., 2019)

ct⁶/ct^A, lncRNA:flam¹/lncRNA:flam^A has increased mortality phenotype

(Guida et al., 2016)

ct⁶, lncRNA:flam¹ has partially lethal - majority live phenotype

(Guida et al., 2016)

Df(2R)exu1/Df(2R)mir-7-Δ1, ct⁶ has visible phenotype

(Aparicio et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

ct⁶, mod(mdg4)^ul has wing margin | adult stage phenotype, enhanceable by shep^d05714

(Chen et al., 2019)

ct⁶, mod(mdg4)^ul has wing phenotype, enhanceable by T7\RpT7^{UAS.Tag:NLS(SV40-largeT)}/Scer\GAL4^Ser.PU/su(Hw)^T7.Tag:MYC

(Matzat et al., 2013)

ct⁶, mod(mdg4)^ul has wing phenotype, enhanceable by T7\RpT7^{UAS.Tag:NLS(SV40-largeT)}/Cp190^T7.Tag:MYC/Scer\GAL4^Ser.PU

(Matzat et al., 2013)

ct⁶, mod(mdg4)^ul has wing margin phenotype, enhanceable by lwr⁰⁵⁴⁸⁶/Sumo⁰⁴⁴⁹³

(Capelson and Corces, 2006)

ct⁶, mod(mdg4)^ul has wing margin phenotype, enhanceable by lwr⁰²⁸⁵⁸/Sumo^k06307

(Capelson and Corces, 2006)

NOT Enhanced by

Statement

Reference

ct⁶ has phenotype, non-enhanceable by brm[+]/brm²

(Krupp et al., 2005)

ct⁶ has phenotype, non-enhanceable by Scer\GAL4^bbg-C96/brm^{K804R.UAS.Tag:HA}

(Krupp et al., 2005)

ct⁶ has phenotype, non-enhanceable by mor[+]/mor¹

(Krupp et al., 2005)

Suppressed by

Statement

Reference

ct⁶, y² has wing margin phenotype, suppressible by HIPP1^UAS.mCh/Scer\GAL4^vg.PM

(Stow et al., 2022)

ct⁶, mod(mdg4)^ul, shep^d05714 has wing margin | adult stage phenotype, suppressible | partially by Scer\GAL4^Ser.PGF/shep^UAS.E

(Chen et al., 2019)

ct⁶ has wing margin phenotype, suppressible by Topors^Z4522/nbl[+]

(Matsui et al., 2011)

ct⁶ has wing margin phenotype, suppressible by Topors^Z1837/nbl[+]

(Matsui et al., 2011)

ct⁶ has wing margin phenotype, suppressible by Topors[+]/Topors^f05115

(Matsui et al., 2011)

ct⁶ has wing phenotype, suppressible by Scer\GAL4^bbg-C96/Top2^GD4570

(Ramos et al., 2011)

ct⁶ has wing phenotype, suppressible by su(Hw)^GD4493/Scer\GAL4^bbg-C96

(Ramos et al., 2011)

ct⁶, mod(mdg4)^T6 has wing margin phenotype, suppressible by Cp190^En15

(Oliver et al., 2010)

ct⁶ has wing margin phenotype, suppressible by Cp190^En15/Cp190^P11

(Oliver et al., 2010)

ct⁶ has wing margin phenotype, suppressible by Cp190^H4-1

(Oliver et al., 2010)

ct⁶ has wing margin phenotype, suppressible by Cp190^P1/Cp190^En15

(Oliver et al., 2010)

ct⁶ has wing margin phenotype, suppressible by mod(mdg4)^ul

(Golovnin et al., 2008, Capelson and Corces, 2006, Capelson and Corces, 2005, Cai and Levine, 1997)

ct⁶ has wing margin phenotype, suppressible by mod(mdg4)^T6

(Golovnin et al., 2008)

ct⁶, mod(mdg4)^ul has adult cuticle phenotype, suppressible by lwr⁰⁵⁴⁸⁶/Sumo⁰⁴⁴⁹³

(Capelson and Corces, 2006)

ct⁶, mod(mdg4)^ul has adult cuticle phenotype, suppressible by lwr⁰²⁸⁵⁸/Sumo^k06307

(Capelson and Corces, 2006)

ct⁶, mod(mdg4)^ul has wing margin phenotype, suppressible by lwr⁰⁵⁴⁸⁶/Sumo⁰⁴⁴⁹³

(Capelson and Corces, 2006)

ct⁶, mod(mdg4)^ul has wing margin phenotype, suppressible by lwr⁰²⁸⁵⁸/Sumo^k06307

(Capelson and Corces, 2006)

ct⁶ has wing margin bristle phenotype, suppressible by Scer\GAL4^bbg-C96/BacA\p35^UAS.cHa

(Krupp et al., 2005)

ct⁶ has wing blade phenotype, suppressible by Scer\GAL4^bbg-C96/BacA\p35^UAS.cHa

(Krupp et al., 2005)

ct⁶ has phenotype, suppressible by chic^GS-A2665/Scer\GAL4^bbg-C96

(Krupp et al., 2005)

ct⁶ has phenotype, suppressible by Scer\GAL4^bbg-C96/lola^GS-A916

(Krupp et al., 2005)

ct⁶ has wing phenotype, suppressible by mod(mdg4)^T6

(Mongelard et al., 2002)

ct⁶ has wing phenotype, suppressible by mod(mdg4)^ul

(Mongelard et al., 2002, Bezborodova et al., 1997)

ct⁶, mod(mdg4)^ul has wing phenotype, suppressible by Su(mg)1-7^1-7

(Bezborodova et al., 1997)

ct⁶ has wing phenotype, suppressible by Scer\GAL4^bbg-C96/Hsap\CUX1^UAS.cLa

(Ludlow et al., 1996)

ct⁶ has wing phenotype, suppressible by Scer\GAL4^bbg-C96/Mmus\Cux1^UAS.cLa

(Ludlow et al., 1996)

ct⁶ has medial row of triple row of wing sensilla phenotype, suppressible by Scer\GAL4^bbg-C96/Mmus\Cux1^UAS.cLa

(Ludlow et al., 1996)

ct⁶ has dorsal row of double row of wing sensilla phenotype, suppressible by Scer\GAL4^bbg-C96/Mmus\Cux1^UAS.cLa

(Ludlow et al., 1996)

ct⁶ has chemosensory ventral triple row bristle phenotype, suppressible by Scer\GAL4^bbg-C96/Mmus\Cux1^UAS.cLa

(Ludlow et al., 1996)

ct⁶ has mechanosensory ventral triple row bristle phenotype, suppressible by Scer\GAL4^bbg-C96/Mmus\Cux1^UAS.cLa

(Ludlow et al., 1996)

ct⁶ has wing & macrochaeta | posterior phenotype, suppressible by Scer\GAL4^bbg-C96/Mmus\Cux1^UAS.cLa

(Ludlow et al., 1996)

ct^L32/ct⁶ has wing phenotype, suppressible by su(Hw)^e2

(Morcillo et al., 1996)

ct⁶ has phenotype, suppressible by su(Hw)^e2

(Dorsett, 1993)

ct⁶ has phenotype, suppressible by su(Hw)^u1

(Georgiev and Gerasimova, 1989)

ct⁶ has phenotype, suppressible by su(Hw)^u2

(Georgiev and Gerasimova, 1989)

ct⁶ has phenotype, suppressible by su(Hw)²

(Georgiev and Gerasimova, 1989, Lindsley and Grell, 1968)

NOT suppressed by

Statement

Reference

ct⁶, y² has wing margin phenotype, non-suppressible by HIPP1^ΔCLD31.2/HIPP1^ΔCLD14.3

(Stow et al., 2022)

ct⁶, mod(mdg4)^ul, shep^d05714 has wing margin | adult stage phenotype, non-suppressible by shep^RRM.UAS.E/Scer\GAL4^Ser.PGF

(Chen et al., 2019)

ct⁶ has wing margin phenotype, non-suppressible by Topors^Z4522/Topors^Z4522

(Matsui et al., 2011)

ct⁶ has wing margin phenotype, non-suppressible by Topors^Z1837/Topors^Z1837

(Matsui et al., 2011)

ct⁶ has wing margin phenotype, non-suppressible by Topors^f05115/Topors^f05115

(Matsui et al., 2011)

ct⁶ has phenotype, non-suppressible by brm[+]/brm²

(Krupp et al., 2005)

ct⁶ has phenotype, non-suppressible by Scer\GAL4^bbg-C96/brm^{K804R.UAS.Tag:HA}

(Krupp et al., 2005)

ct⁶ has phenotype, non-suppressible by mor[+]/mor¹

(Krupp et al., 2005)

ct⁶ has wing phenotype, non-suppressible by mod(mdg4)^L3101/mod(mdg4)^ul

(Mongelard et al., 2002)

ct⁶ has wing phenotype, non-suppressible by mod(mdg4)^neo129/mod(mdg4)^ul

(Mongelard et al., 2002)

ct⁶ has wing phenotype, non-suppressible by mod(mdg4)^UASp.cMa/Scer\GAL4^Act5C.PI/mod(mdg4)^ul

(Mongelard et al., 2002)

Other

Statement

Reference

ct⁶, y² has wing margin phenotype

(Stow et al., 2022)

ct⁶, mod(mdg4)^ul has wing margin | adult stage phenotype

(Chen et al., 2019)

Df(2R)exu1/Df(2R)mir-7-Δ1, ct⁶ has wing phenotype

(Aparicio et al., 2015)

ct⁶, mod(mdg4)^T6 has wing margin phenotype

(Oliver et al., 2010)

Chi[+]/Chi^e5.5, ct⁶ has wing phenotype

(Morcillo et al., 1996)

ct⁶, su(Hw)^e2 has wing phenotype

(Morcillo et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

ct⁶, flam¹ double homozygotes present significant lethality during the pharate stage, as compared to both ct⁶ and flam¹ single homozygotes.

flam^A/flam¹, ct^A/ct⁶ double transheterozygotes show a small but significant increase in mortality as compared to flam^A/flam¹ single heterozygotes.

(Guida et al., 2016)

ct⁶/+ suppresses the severity of decreases in wing size seen in Df(2R)mir-7-Δ1/Df(2R)exu1 flies.

(Aparicio et al., 2015)

Expression of su(Hw)^{T7.T:Hsap\MYC} (in the presence of T7\RpT7^{Scer\UAS.T:SV40\nls2} under the control of Scer\GAL4^Ser.PU, and in a sensitised mod(mdg4)^ul mutant background) enhances the wing notching phenotype seen in ct⁶ mutants compared to controls.

Expression of Cp190^{T7.T:Hsap\MYC} (in the presence of T7\RpT7^{Scer\UAS.T:SV40\nls2} under the control of Scer\GAL4^Ser.PU, and in a sensitised mod(mdg4)^ul mutant background) enhances the wing notching phenotype seen in ct⁶ mutants compared to controls.

(Matzat et al., 2013)

Heterozygosity, but not homozygosity, for Topors^Z4522, Topors^Z1837 or Topors^f05115 restores the wing margin of ct⁶ flies.

(Matsui et al., 2011)

Expression of Top2^GD4570 in the prospective wing margin region of the developing wing under the control of Scer\GAL4^bbg-C96 results in a decrease in gypsy insulator function and suppresses the ct⁶ phenotype back to wild-type.

Expression of su(Hw)^GD4493 in the prospective wing margin region of the developing wing under the control of Scer\GAL4^bbg-C96 results in a decrease in gypsy insulator function and suppresses the ct⁶ phenotype back to wild-type.

(Ramos et al., 2011)

The wing margin phenotype of ct⁶ mutants is partially suppressed by Cp190^En15/Cp190^P11.

The wings of ct⁶; mod(mdg4)^T6 mutants have underdeveloped margins.

The wing margin phenotype of ct⁶; mod(mdg4)^T6 mutants is fully suppressed by Cp190^En15.

The ct⁶ wing margin phenotype is partially suppressed by Cp190^H4-1.

The ct⁶ wing margin phenotype is fully suppressed by Cp190³/Cp190^P1.

(Oliver et al., 2010)

mod(mdg4)^ul and mod(mdg4)^T6 mutations both suppress the "cut" wing phenotype observed in ct⁶ mutant flies, and the wing margins are fully restored in these animals.

(Golovnin et al., 2008)

ct⁶ mod(mdg4)^ul double mutants exhibit a suppression of the ct⁶ jagged wing edge.

The transheterozygote lwr⁰⁵⁴⁸⁶/smt3⁰⁴⁴⁹³ suppresses the mod(mdg4)^ul suppression of the ct⁶ jagged wing phenotype, leading to a more jagged and discontinuous wing phenotype. The phenotype is also particularly pronounced in females, although it is detectable in both sexes.

The transheterozygote lwr⁰²⁸⁵⁸/smt3^k06307 suppresses the mod(mdg4)^ul suppression of the ct⁶ jagged wing phenotype, leading to a more jagged and discontinuous wing phenotype. The phenotype is also particularly pronounced in females, although it is detectable in both sexes.

(Capelson and Corces, 2006)

Expression of Topors^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^Act partially suppresses the ability of mod(mdg4)^ul to suppress the cut wing margin phenotype of ct⁶.

Expression of Topors^{C118S.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^hs.PB does not suppress the ability of mod(mdg4)^ul to suppress the cut wing margin phenotype of ct⁶.

(Capelson and Corces, 2005)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^C96 suppresses the loss of wing blade tissue, including the slender recurved chemosensory wing margin bristles, seen in ct⁶ flies, but does not rescue the loss of the stout mechanosensory wing margin bristles.

(Krupp et al., 2005)

The shape and margins of the wings in y² ct⁶; Df(3R)E(mod)4-1^P11/Cp190^H53-2 flies are normal, indicating complete suppression of ct⁶.

The wings of y² ct⁶; Cp190^H4-1 male flies are rounder in shape, suggesting that ct⁶ is partially suppressed, whereas the bristles are yellow, indicating that the y² phenotype is altered. The body cuticle colour is only slightly darker in the background of the Cp190^H4-1 mutation.

(Pai et al., 2004)

The ct⁶ wing margin phenotype is suppressed in ct⁶ mod(mdg4)^ul double homozygotes, resulting in the restoration of the wing margin.

(Cai and Levine, 1997)

In combination with e(y)2¹ and z^op6, mod(mdg4)^ul almost completely suppresses the mutant phenotype of ct⁶. In combination with e(y)3⁴ and z^v77h, mod(mdg4)^ul enhances the mutant phenotype of ct⁶, though the gaps in the wing margin are still randomly distributed. z¹ and e(y)1¹ have no effect on the mod(mdg4)^ul effect on ct⁶.

(Melnikova et al., 1996)

ct⁶; su(Hw)^e2 flies display a scalloped cut wing phenotype with multiple nicks. Chi^e5.5; ct⁶ double heterozygotes display a visible cut wing phenotype.

(Morcillo et al., 1996)

Phenotype is partially suppressed by mod(mdg4)^ul at 25^oC, and completely suppressed by mod(mdg4)^ul at 18^oC.

(Georgiev and Gerasimova, 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

ct⁶ is partially rescued by Scer\GAL4^bbg-C96/ct^UAS.cPa

(Krupp et al., 2005)

Comments

Expression of mod(mdg4)^Scer\UAS.cGa or mod(mdg4)^ΔQ.Scer\UAS under the control of Scer\GAL4^Act5C in a ct⁶,mod(mdg4)^ul mutant background suppresses the effect that mod(mdg4)^ul has on ct⁶ wings, and the wings that form lack the wing margin and are similar to ct⁶ wings.

(Golovnin et al., 2008)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (61)

Bloomington

cm¹ ct⁶

1502

z^a694 ct⁶

3169

cm¹ ct⁶ mys^ts1

1976

w¹ mus105^A1 ct⁶

101

sc¹ z¹ ec¹ ct⁶

59960

y² w¹ ct⁶; mod(mdg4)^ul

ec¹ ct⁶ Ype^s-1 car¹/FM6

6036

y¹ w¹ ct⁶ m¹ f¹

Kyoto

105674

bi¹ ct⁶ g²

106890

cm¹ ct⁶ mys^ts1

105734

sc¹ z¹ ec¹ ct⁶

105690

ec¹ ct⁶ Ype^s-1 car¹/FM6

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Notes on Origin

Discoverer

Bridges, 20th March 1920.

Comments

Highly unstable, showing increased incidence of lethal mutations, many of which are associated with chromosome aberrations broken in 6F (Lim). The gypsy sequence appears to be mobilized and transposed into other parts of the ct locus to produce new ct alleles or, when ct undergoes reversion, to other positions in the genome. Allele most used as genetic marker.

cut wing phenotypic class.

(Blochlinger et al., 1990)

Regulatory mutant.

(Ostrow and Blochlinger, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Name Synonyms

cut6

(Matzat et al., 2013, Capelson and Corces, 2006)

Secondary FlyBase IDs

References (73)

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