FlyBase Allele Report: Dmel\ci[W]

General Information

Symbol

Dmel\ci^W

Species

D. melanogaster

Name

of Wallace

FlyBase ID

FBal0001653

Feature type

allele

Associated gene

Dmel\ci

Associated Insertion(s)

?{}ci^W

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

gain of function allele

(Dominguez, 1999)

Mutagen

spontaneous

(Slusarski et al., 1995)

Progenitor genotype

Associated Insertion(s)

?{}ci^W

Cytology

Description

Uncharacterised alterations located 5' to the transcription unit and 10kb 3' to the transcription unit.

(Slusarski et al., 1995)

Single 6.4kb insertion in the PstI HaeIII fragment.

(Locke and Tartof, 1994)

4.0 kb insert, Different from the insert in ci³⁶. ci¹, ci³⁶, ci⁵⁷, ci^D and ci^W mutant in the same 5.8 kb Bgl fragment. This fragment hybridizes to a 2.0 kb RNA that shows peak concentrations in late pupae.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Sanchez-Herrero et al., 1996)

visible | dominant

(Campbell and Tomlinson, 2000, Svendsen et al., 2000, Diaz-Benjumea and Garcia-Bellido, 1990)

visible | dominant | cold sensitive

(Locke and Hanna, 1996)

Phenotype Manifest In

leg (with ci^D)

(Sanchez-Herrero et al., 1996)

ommatidial precursor cluster

(Dominguez, 1999)

wing

(Dominguez et al., 1996)

wing blade anterior compartment

(Sanchez-Herrero et al., 1996)

wing vein

(Locke and Hanna, 1996)

wing vein L4

(Campbell and Tomlinson, 2000, Svendsen et al., 2000)

Detailed Description

Statement

Reference

Heterozygotes show variable loss of vein L4 tissue.

(Campbell and Tomlinson, 2000)

Heterozygotes show wing vein L4 defects.

(Svendsen et al., 2000)

When analysed in large clones in the developing eye the packing in the ommatidial clusters is disrupted.

(Dominguez, 1999)

Wings from homozygotes have, at low penetrance, a mirror symmetrical outgrowth composed of anterior wing material, resembling duplications caused by ectopic dpp expression.

(Dominguez et al., 1996)

Homozygotes occasionally show overgrowth in the anterior compartment of the wing. ci^D/ci^W flies have abnormal legs.

(Sanchez-Herrero et al., 1996)

Homozygous viable.

(Locke and Tartof, 1994)

Lack all longitudinal and transverse veins and affect morphogenesis of legs and eyes.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Homozygote is extreme ci type. Wings sometimes almost twice normal width, arclike, and virtually lack veins. Often present is a well-organized pattern of venation in which the posterior crossvein flows smoothly into L5. Legs lumpy, sex combs larger than normal, antennae enlarged, eyes smaller and extra bristles present. Heterozygote shows gap in L4 in 80% of flies. ci^W enhanced by H, en, and Cy (House, 1953c; House 1959) and by Tp(4;Y) (Benner, 1972). Temperature effect described by House (1955b). RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ci^W has visible | dominant phenotype, enhanceable by cg[+]/cg³

(Svendsen et al., 2000)

ci^W has visible | dominant phenotype, enhanceable by cg[+]/cg⁰⁷⁶⁵⁹

(Campbell and Tomlinson, 2000, Svendsen et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

ci^W has wing phenotype, enhanceable by Psc¹

(Randsholt et al., 2000)

ci^W has wing phenotype, enhanceable by ph-p⁴¹⁰

(Randsholt et al., 2000)

ci^W has wing vein L4 phenotype, enhanceable by cg[+]/cg³

(Svendsen et al., 2000)

ci^W has wing vein L4 phenotype, enhanceable by cg[+]/cg⁰⁷⁶⁵⁹

(Campbell and Tomlinson, 2000, Svendsen et al., 2000)

ci^W has wing phenotype, enhanceable by en^Enci

(Locke and Hanna, 1996)

ci^W has phenotype, enhanceable by cg¹

(House, 1953)

Suppressed by

Statement

Reference

ci^W has wing phenotype, suppressible by Dp(1;2;Y)w⁺

(Randsholt et al., 2000)

NOT suppressed by

Statement

Reference

ci^W/ci^D has leg phenotype, non-suppressible by fu^J

(Sanchez-Herrero et al., 1996)

ci^W/ci^D has wing phenotype, non-suppressible by fu^J

(Sanchez-Herrero et al., 1996)

ci^W has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Additional Comments

Genetic Interactions

Statement

Reference

The ci^W/+ wing vein L4 phenotype is enhanced by one copy of cg⁰⁷⁶⁵⁹.

(Campbell and Tomlinson, 2000)

The wing vein L4 defects observed in ci^W/+ heterozygotes are enhanced by one copy of cg⁰⁷⁶⁵⁹ or cg³.

(Svendsen et al., 2000)

Wing phenotype is enhanced by en^Enci at 18^oC.

(Locke and Hanna, 1996)

The wing and leg phenotypes of ci^D/ci^W flies are not altered by fu^J.

(Sanchez-Herrero et al., 1996)

When doubly heterozygous with en loss of function alleles, the dominant ci phenotype is enhanced. Three doses of en⁺ suppress expression of the ci phenotype in ci^W heterozygotes.

(Locke and Hanna, 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

ci^Ce-r1

(Kronhamn and Rasmuson-Lestander, 1999)

Fails to complement

ci^Ce-2

(Kronhamn and Rasmuson-Lestander, 1999)

ci^D