FlyBase Allele Report: Dmel\ci[57]

General Information

Symbol

Dmel\ci⁵⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0001646

Feature type

allele

Associated gene

Dmel\ci

Associated Insertion(s)

Carried in Construct

Also Known As

ci^57g

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Hochman et al., 1964, Volkers, 1957)

Progenitor genotype

Cytology

Description

Deletion of 646bp and an insertion of 29bp at the same site within the 2.2dis element, located 2.5kb upstream from the start of transcription.

(Schwartz et al., 1995)

Small deletion in the PstI HaeIII fragment that removes or alters the PstI site, results in deletion of a transcriptional silencer element.

(Locke and Tartof, 1994)

800 bp deletion ci¹, ci³⁶, ci⁵⁷, ci^D and ci^W mutant in the same 5.8 kb Bgl fragment. This fragment hybridizes to a 2.0 kb RNA that shows peak concentrations in late pupae.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

4:59,892..60,534 [-]

Inserted_sequence:

AATTTATTTATTAACTGAATAAATTATTT

Comment:

Deletion of 646bp and an insertion of 29bp (AATTTATTTATTAACTGAATAAATTATTT) at the same site.

(Schwartz et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Locke and Hanna, 1996, Schwartz et al., 1995, Hochman et al., 1964)

Phenotype Manifest In

wing blade posterior compartment

(Schwartz et al., 1995)

wing vein

(Locke and Hanna, 1996, Schwartz et al., 1995, Locke and Tartof, 1994)

Detailed Description

Statement

Reference

Does not affect embryonic development but causes an adult phenotype, vein defects in the posterior compartment of the wing.

(Schwartz et al., 1995)

Coordinate mutant.

(Sturtevant and Bier, 1995)

Wing vein interruption. Homozygous viable.

(Locke and Tartof, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

ci⁵⁷ has phenotype, enhanceable by en¹

(Locke and Hanna, 1996)

ci⁵⁷ has phenotype, enhanceable by en⁴

(Locke and Hanna, 1996)

ci⁵⁷ has phenotype, enhanceable by en⁵⁹

(Locke and Hanna, 1996)

ci⁵⁷ has wing phenotype, enhanceable by en^Enci

(Locke and Hanna, 1996)

NOT suppressed by

Statement

Reference

ci⁵⁷ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Additional Comments

Genetic Interactions

Statement

Reference

Wing phenotype is enhanced by en^Enci at 18^oC.

(Locke and Hanna, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

ci^Ce-r1