FlyBase Allele Report: Dmel\ci[1]

General Information

Symbol

Dmel\ci¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001644

Feature type

allele

Associated gene

Dmel\ci

Associated Insertion(s)

gypsy{}ci¹

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Orenic et al., 1990)

Progenitor genotype

Associated Insertion(s)

gypsy{}ci¹

Cytology

Description

Insertion of a gypsy element.

(Slusarski et al., 1995)

Single complete 7.3kb gypsy insertion at map coordinate 0, on the PstI HaeIII fragment.

(Locke and Tartof, 1994)

Gypsy insertion.

(Orenic et al., 1990)

ci¹, ci³⁶, ci⁵⁷, ci^D and ci^W mutant in the same 5.8 kb Bgl fragment. This fragment hybridizes to a 2.0 kb RNA that shows peak concentrations in late pupae. gypsy insert

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Locke and Hanna, 1996, Slusarski et al., 1995, Orenic et al., 1990)

Phenotype Manifest In

wing vein

(Locke and Hanna, 1996)

wing vein L4

(Slusarski et al., 1995)

wing vein L5

(Slusarski et al., 1995)

Detailed Description

Statement

Reference

Disruptions in wing veins 4 and 5. Complements the segmentation defects of pan^13a and ci^Ce-r2. Mutant wing phenotype is suppressed by su(Hw) mutations.

(Slusarski et al., 1995)

Homozygous viable. Phenotype can be suppressed by su(Hw)².

(Locke and Tartof, 1994)

Wing venation defect. Suppressible by su(Hw).

(Orenic et al., 1990)

Vein L4 shows one or more gaps both distal and proximal to posterior crossvein, generally nonterminal. Anterior crossvein shortened or absent. Other gaps and scattered branch veins in region of crossveins. At 19^oC, nearly all flies have a mutant phenotype; at 25^oC, there is slight overlap with wild type; at 30^oC, virtually all flies are wild type. Dosage effect such that ci/0 haplo-4's are more extreme than ci/ci diplo-4's, which are more extreme than ci/ci/ci triplo-4's. Suppressed by su(Hw)² (Kotarski). For interactions of ci with en, H, ve and cg, see House (House, 1953a) (House, 1955) (House, 1959) (House, 1961). Expression of ci sensitive to genetic background; selection possible for more and less extreme phenotypes (House and Yeatts, 1962); contribution of chromosome 2 more important than that of 3 (House and Pernaveau, 1971). Phenotypic effect visible in prepupa by absence of the longer longitudinal vein. RK1 at 19^oC and higher rank with higher temperatures.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

ci¹ has phenotype, enhanceable by en¹

(Locke and Hanna, 1996)

ci¹ has phenotype, enhanceable by en⁴