FB2024_03 , released June 25, 2024
Allele: Dmel\Cdk1D57
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General Information
Symbol
Dmel\Cdk1D57
Species
D. melanogaster
Name
FlyBase ID
FBal0001572
Feature type
allele
Associated gene
Dmel\Cdk1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Tio et al., 2001, Stern et al., 1993)
Mutagen
ethyl methanesulfonate
(Clegg et al., 1993, Stern et al., 1993)
Progenitor genotype
Cytology
Description

Amino acid replacement: G148R. Nucleotide substitution: Mutation of GGA to AGG.

(Clegg et al., 1993)

Missense mutation: glycine replaced by arginine in a position that is completely invariant in known cdc2 homologs.

(Stern et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:10,385,351..10,385,351 [-]
Nucleotide change:

G10385351A

Reported nucleotide change:

G?A

Amino acid change:

G148R | Cdk1-PA

Reported amino acid change:

G148R

Comment:

Cdk1D57 sequence is in GB:S66804

(Clegg et al., 1993, Stern et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
S66804
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethal phase is during the larval/pupal stage. Homozygous embryos develop essentially normally. RP2 neuron duplication and large RP2 neurons are seen in only 0.8% of cases.

      (Tio et al., 2001)

      Die after pupariation at the larval-pupal interface when the allele is inherited from the male. Weak maternal antimorphic effect is seen: if the cdc2D57 allele is provided from the female, the lethality acts embryonically. Larvae take 1-2 days longer than wild type to reach the wandering stage. Imaginal discs are missing or rudimentary and larval brains are reduced in size. Endoreplication and polytenization of larval cells is normal, as are salivary gland size and intensity of DNA staining of their polytene nuclei.

      (Stern et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      cdc2[+]/Cdk1D57 is a suppressor of aster | embryonic cycle 5 phenotype of CycB+t10

      (Ji et al., 2002)

      cdc2[+]/Cdk1D57 is a suppressor of aster | embryonic cycle 6 phenotype of CycB+t10

      (Ji et al., 2002)

      cdc2[+]/Cdk1D57 is a suppressor of aster | embryonic cycle 7 phenotype of CycB+t10

      (Ji et al., 2002)

      cdc2[+]/Cdk1D57 is a suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB+t10

      (Ji et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cdk1D57
      cdc2D57
      cdk1D57
      (Ji et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)