FlyBase Allele Report: Dmel\cact[9]

General Information

Symbol

Dmel\cact⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0001515

Feature type

allele

Associated gene

Dmel\cact

Associated Insertion(s)

Carried in Construct

Also Known As

cact^IIIG

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ashburner et al., 1999.10.12, Roth et al., 1991, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | maternal effect | recessive

lethal | recessive

(Qiu et al., 1998)

lethal - all die before end of pupal stage (with cact^E8)

(Dolezal et al., 2005)

melanotic mass phenotype | third instar larval stage (with cact^E8)

(Dolezal et al., 2005)

some die during pupal stage (with cact^E8)

(Dolezal et al., 2005)

Phenotype Manifest In

embryonic/larval hemocyte (with cact^E8)

(Dolezal et al., 2005)

embryonic dorsal epidermis

(Roth et al., 1991)

melanotic mass | third instar larval stage (with cact^E8)

(Dolezal et al., 2005)

Detailed Description

Statement

Reference

The number of circulating hemocytes is increased in cact^E8/cact⁹ third instar larvae compared to wild-type.

(Dolezal et al., 2005)

cact^E8/cact⁹ larvae are viable at 24 and 48 hours after fertilisation. More than 80% of the larvae survive to 120 hours after fertilisation and progress into pupal stages. Less than 1% of these animals eclose, the majority dying as pupae. Approximately 40% of larvae have melanotic capsules.

(Qiu et al., 1998)

Strong ventralizing phenotype: lack of all dorsally and laterally derived structures and the expansion of the ventral epidermis around the entire circumference. Expansion of twi expression in terminal regions.

(Roth et al., 1991)

Very strong cact allele.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

cact⁹/cact^E8 has melanotic mass phenotype | third instar larval stage phenotype, suppressible | partially by Adgf-A^hs.PD

(Dolezal et al., 2005)

cact⁹/cact^E8 has lethal | pupal stage phenotype, suppressible | heat sensitive | partially by Adgf-A^hs.PD

(Dolezal et al., 2005)

Phenotype Manifest In

Suppressed by

Statement

Reference

cact⁹/cact^E8 has melanotic mass | third instar larval stage phenotype, suppressible | partially by Adgf-A^hs.PD

(Dolezal et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

cact⁹

cact^IIIG

(Dolezal et al., 2005, Qiu et al., 1998, Roth et al., 1991, Tearle and Nusslein-Volhard, 1987)

cactus^IIIG

(Novakova and Dolezal, 2011)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close