FB2024_03 , released June 25, 2024
Allele: Dmel\br6
Open Close
General Information
Symbol
Dmel\br6
Species
D. melanogaster
Name
FlyBase ID
FBal0001193
Feature type
allele
Associated gene
Dmel\br
Associated Insertion(s)
Carried in Construct
Also Known As
brlt103, lt103
Key Links
Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Liu and Restifo, 1998, Kiss et al., 1988)

loss of function allele

(DiBello et al., 1991)
Mutagen
ethyl methanesulfonate
(Kiss et al., 1988, Belyaeva et al., 1982)
Progenitor genotype
Caused by aberration
In(1)br103
Cytology
Description

Breakpoint at 146 to 151 kb.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The posterolateral medulla is fused with the adjacent lobula plate in hemizygous flies. Optic lobe position is abnormal.

      (Liu and Restifo, 1998)

      Failure of salivary gland degeneration. Reduction in dorso-ventral class of indirect flight muscles. Some show proventriculus abnormality: foregut-midgut junction less proventriculus-like in appearance.

      (Restifo and White, 1992)

      41% penetrance of abnormal SEG-TG separation phenotype, 55% of individuals show an abnormal optic lobe position and 35% a brain fusion failure.

      (Restifo and White, 1991)

      'rbp' and br phenotype. Development of the early ecdysone puff in region 2B3--2B5 is not affected.

      (Belyaeva et al., 1987)

      Lethal period is between pupal ecdysis and formation of the nonpigmented pupal legs and wings.

      (Belyaeva et al., 1982)

      br6/br7 combination is lethal. Few adult escapers survive with short, broad wings. Adults of the br6/brrbp-3 or br6/brrbp-4 combination have reduced number of bristles on the palpus and have short, broad wings. Heterozygotes with Df(1)br25 have reduced viability and br wings.

      (Belyaeva et al., 1980)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      brnpr-6

      (Tzolovsky et al., 1999)
      Fails to complement

      br7

      (Belyaeva et al., 1980)
      Comments

      br6/+ x brnpr-6/+ crosses lead to transheterozygous males but no females being produced. Offspring die as pupae.

      (Tzolovsky et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Deficient in 'rbp' function.

      (Kiss et al., 1988)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      br103
      (Sampedro et al., 1989)
      br6
      brlt103
      (Mazina et al., 1991, Mazina et al., 1990)
      l(1)t103
      lt103
      (Belyaeva et al., 1982, Belyaeva et al., 1980)
      Name Synonyms
      Secondary FlyBase IDs
        References (14)