FB2024_03 , released June 25, 2024
Allele: Dmel\bib7
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General Information
Symbol
Dmel\bib7
Species
D. melanogaster
Name
FlyBase ID
FBal0001131
Feature type
allele
Associated gene
Dmel\bib
Associated Insertion(s)
Carried in Construct
Also Known As
bibFX1
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Lehmann et al., 1983)
Mutagen
X ray
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The number of cells in the nau-expressing muscle precursor clusters is increased compared to wild-type in homozygous embryos and in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function). The medial clusters expand across the midline.

      (Rusconi and Corbin, 1998)

      bib7/bib8 embryos develop a hypertrophic nervous system at the expense of ventral cuticle. Homozygous clones in adult flies have moderately increased numbers of macrochaetae and microchaetae. These bristles have normal sockets innervated by single neurons. Homozygous clones in adult flies have moderately increased numbers of macrochaetae and microchaetae. These bristles have normal sockets innervated by single neurons.

      (Doherty et al., 1997)

      Intermediate embryonic neurogenic phenotype.

      (Lehmann et al., 1983)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      bib7 is a non-suppressor of phenotype of Src42ASu(Raf)1-1

      (Zhang et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Does not suppress the ability of Src42ASu(phl)1-1 to suppress the lethality of phl1/Y flies.

      (Zhang et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      bib7/bib8 is rescued by bibUAS.cDa/Scer\GAL4h-1J3

      (Doherty et al., 1997)
      Comments

      These embryos are rescued by bibScer\UAS.cDa expressed under the control of Scer\GAL4h-1J3, producing embryos with nearly wild-type thoracic and abdominal cuticle without any missing denticle belts in some cases. Hypertrophy of the peripheral nervous system is also reduced in these embryos.

      (Doherty et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Campos-Ortega.

      Comments
      Comments

      Clonal analysis indicates that bib functions autonomously to inhibit neural development.

      (Doherty et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      bib7
      bibFX1
      (Zhang et al., 1999, Rusconi and Corbin, 1998, Doherty et al., 1997, Lehmann et al., 1983)
      bibFx1
      (Rhyu et al., 1994)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)