FlyBase Allele Report: Dmel\ash1[4]

General Information

Symbol

Dmel\ash1⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0000734

Feature type

allele

Associated gene

Dmel\ash1

Associated Insertion(s)

Carried in Construct

Also Known As

ash1^RE418

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Tripoulas et al., 1996)

Mutagen

ethyl methanesulfonate

(Tripoulas et al., 1996, Tripoulas et al., 1994)

Progenitor genotype

Cytology

Description

Amino acid replacement: K875term.

(Tripoulas et al., 1996)

Nucleotide substitution: A3369T.

(Tripoulas et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:19,595,552..19,595,552 [-]

Nucleotide change:

A19595552T

Reported nucleotide change:

A3369T

Amino acid change:

K875term | ash1-PB; K875term | ash1-PC

Reported amino acid change:

K875term

(Tripoulas et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Tripoulas et al., 1994)

lethal - all die before end of larval stage | recessive

(Tripoulas et al., 1996)

some die during larval stage | recessive

(Tripoulas et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

Double heterozygotes with Ubx^abx-1, trx^el2 or brm² exhibit transformation of third leg to second leg identity and haltere to wing transformation.

(Tripoulas et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ash1⁴, sktl[+]/sktl^k07505 has visible | dominant | homeotic phenotype

(Cheng and Shearn, 2004)

ash1⁴, sktl^k07505 has visible | dominant | homeotic phenotype

(Cheng and Shearn, 2004)

+/Df(2L)Mdh, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(2R)trix/+, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(2R)vg-C/+, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(3L)Ar14-8/+, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(3R)by62/+, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

+/Df(2R)en-A, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(2L)cl-h3/+, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(2R)CX1/+, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(2R)Pu-D17/+, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Df(2R)or-BR6/+, ash1⁴ has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

ash1⁴ is a non-enhancer of wing vein | ectopic phenotype of Snr1^R3/Snr1^E1

(Marenda et al., 2004)

ash1⁴ is a non-enhancer of wing phenotype of Snr1^R3/Snr1^E1

(Marenda et al., 2004)

NOT Suppressor of

Statement

Reference

ash1⁴ is a non-suppressor of wing vein | ectopic phenotype of Snr1^R3/Snr1^E1

(Marenda et al., 2004)

ash1⁴ is a non-suppressor of wing phenotype of Snr1^R3/Snr1^E1

(Marenda et al., 2004)

Other

Statement

Reference

ash1⁴, sktl[+]/sktl^k07505 has mesothoracic leg phenotype

(Cheng and Shearn, 2004)

ash1⁴, sktl[+]/sktl^k07505 has metathoracic leg | ectopic phenotype

(Cheng and Shearn, 2004)

ash1⁴, sktl^k07505 has mesothoracic leg phenotype

(Cheng and Shearn, 2004)

ash1⁴, sktl^k07505 has metathoracic leg | ectopic phenotype

(Cheng and Shearn, 2004)

+/Df(2L)Mdh, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(2R)trix/+, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(2R)vg-C/+, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(3L)Ar14-8/+, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(3R)by62/+, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

+/Df(2R)en-A, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(2L)cl-h3/+, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(2R)CX1/+, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(2R)Pu-D17/+, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

Df(2R)or-BR6/+, ash1⁴ has adult metathoracic segment phenotype

(Gildea et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

ash1⁴ sktl^k07505 double heterozygotes show a homeotic transformation of third leg to second leg (7.1% penetrance).

(Cheng and Shearn, 2004)

Double heterozygotes with Df(2L)Mdh, Df(2R)or-BR6, Df(3L)Ar14-8, Df(2L)cl-h3, Df(2R)Pu-D17, Df(2R)en-A, Df(2R)vg-C, Df(2R)CX1, Df(2R)trix or Df(3R)by62 show T3 to T2 transformations. Double heterozygotes with Df(2R)eve, Df(2R)en30, Df(2R)Jp1 or Df(3R)M-Kx1 do not show T3 to T2 transformations. Double heterozygotes with Df(2R)en-A show a frequency of T3 to T2 transformations that is indistinguishable from ash1⁴/+ single heterozygotes.

(Gildea et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

(Tripoulas et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

RE418

(Shearn et al., 1971)

ash1⁴

ash1^RE418

(Goodliffe et al., 2007, Cheng and Shearn, 2004, Gildea et al., 2000)

dash⁶

(Lindsley and Zimm, 1992)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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