FlyBase Allele Report: Dmel\abd-A[iab2-K]

General Information

Symbol

Dmel\abd-A^iab2-K

Species

D. melanogaster

Name

FlyBase ID

FBal0000090

Feature type

allele

Associated gene

Dmel\abd-A

Associated Insertion(s)

gypsy{}abd-A^iab2-K

Carried in Construct

Also Known As

iab-2^k

Key Links

Allele class

gain of function allele

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

gain of function allele

(Busturia et al., 1989)

hypomorphic allele - genetic evidence

(Macias et al., 1990)

Mutagen

spontaneous

(Karch et al., 1985)

Progenitor genotype

Associated Insertion(s)

gypsy{}abd-A^iab2-K

Cytology

Polytene chromosomes normal.

Description

Mutation maps outside the 3' end of the transcription unit.

(Macias et al., 1990)

Insertion of a gypsy element at position +27kb.

(Karch et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Karch et al., 1985)

visible | dominant | homeotic

(Busturia et al., 1989)

visible | homeotic

(Karch et al., 1985)

Phenotype Manifest In

adult abdominal segment 1

(Busturia et al., 1989)

adult abdominal segment 2

(Busturia et al., 1989, Karch et al., 1985)

Detailed Description

Statement

Reference

Partial transposition of A2 towards A1 was observed in homozyous and heterozygous flies. A1 tergite shows some large bristles indicative of transformation towards a more posterior segment. The recessive transformation of A2 to A1 is mostly or entirely due to the activity of the gypsy transposon. Transheterozygous combinations with other 'iab-2'-class alleles display transformation of A2 towards A1.

(Busturia et al., 1989)

Homozygous viable, causes a partial transformation of the adult second abdominal segment into the first.

(Karch et al., 1985)

Heterozygotes with abd-A^S1, abd-A^S2 and abd-A^iab2-S3 exhibit transformation of abdominal segment 2 to segment 1 identity.

(Tiong et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

abd-A^iab2-K has phenotype, enhanceable by su(Hw)²

(Macias et al., 1990, Busturia et al., 1989)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

D. Woods.

(Karch et al., 1985)

Comments

Ectopic expression of the protein after retraction of germ band is enhanced if embryos are also homozygous for su(Hw)² (FBrf0049558).

(Macias et al., 1990)

Homozygotes show little change in abd-A expression pattern.

(Sanchez-Herrero, 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

abd-A^iab2-K

abd-A^iab2-Kuhn

(Karch et al., 1985)

iab-2^k

(Sanchez-Herrero, 1991, Macias et al., 1990, Casanova et al., 1988, Tiong et al., 1985)

iab2^K

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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