FB2024_03 , released June 25, 2024
Allele: Dmel\αTub84B7
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General Information
Symbol
Dmel\αTub84B7
Species
D. melanogaster
Name
FlyBase ID
FBal0000019
Feature type
allele
Associated gene
Dmel\αTub84B
Associated Insertion(s)
Carried in Construct
Also Known As
αTub84Bnc33
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Hutchens et al., 1997)
Mutagen
ethyl methanesulfonate
(Fuller, 1986)
Progenitor genotype
Cytology
Description

Amino acid replacement: V177M.

(Hutchens et al., 1997, Hays et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:7,087,759..7,087,759 [+]
Nucleotide change:

G7087759A

Amino acid change:

V177M | alphaTub84B-PA

Reported amino acid change:

V177M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Hays et al., 1989)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Transheteroallelic combinations produce males that are sterile or weakly fertile.

      (Hutchens et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      alphaTub84B[+]/αTub84B7 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)
      Other
      Statement
      Reference

      αTub84B7, βTub85Dn has male sterile | dominant phenotype

      (Hays et al., 1989)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      alphaTub84B[+]/αTub84B7 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)

      αTub84B7 is an enhancer of phenotype of βTub85Dunspecified

      (Fuller, 1986)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of αTub85EβTub85D.PH partially rescues the defective αTub84B function in spermatogenesis: most spermatids have complete axonemes.

      (Hutchens et al., 1997)

      αTub84B7/βTub85Dn : male heterozygotes are sterile, even in the presence of a wild type copy of αTub84B; this interaction requires the presence of a defective protein as males heterozygous for a deletion of αTub84B7 and βTub85Dn are fertile.

      (Hays et al., 1989)

      Fails to complement class I alleles at the βTub85D locus.

      (Fuller, 1986)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      K.J. Kemphues.

      Selected as: a mutation that fails to complement class I alleles at the βTub85D locus (either βTub85D3 or βTub85DDrv1) but does not map to the βTub85D locus.

      (Fuller, 1986)
      Comments
      Comments

      Identification: Second site non-complementation with an allele of βTub85D. Same second site non-complementation results are seen when a cloned copy of αTub84B7 is inserted in a P element into different places than its usual genomic location.

      (Hays et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      ms(3)nc33
      nc33
      (Fuller, 1986)
      α-tubulin84B7
      (Simonsen et al., 2007)
      αTub84B7
      αTub84Bnc33
      (Hutchens et al., 1997, Hays et al., 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)