FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(3R)Tl-X
Open Close
General Information
Symbol
Df(3R)Tl-X
Species
D. melanogaster
Name
Deficiency (3R) Toll
FlyBase ID
FBab0002668
Feature type
chromosomal_deletion
Also Known As
Df(3R)Tl9QRX, Tl9QRX, Df(3R)Tl9QRX
Computed Breakpoints include

97B;97D1-97D2

Features within 97B--97D2
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Tl3
(Anderson et al., 1985)
Mutagen
X ray
(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Pauli et al., 1995, Karsch-Mizrachi and Haynes, 1993, Anderson et al., 1985)
Breakpoints

97B;97D

(Anderson et al., 1985)

97B;97D1-97D2

(Pauli et al., 1995, Karsch-Mizrachi and Haynes, 1993)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk2 hits Tl

Genetic mapping information
Comments

The 97D1-2 breakpoint is located in the 6.0 kb EcoRI fragment of the Toll clone (Hashimoto, Hudson and Anderson, 1988, Cell 52: 269-79)

Comments on Cytology

Limits of break 1 from polytene analysis (FBrf0042050) Left limit of break 2 from inclusion of Tl (FBrf0042050) Right limit of break 2 from polytene analysis (FBrf0059186)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In this case, the "Export to Hitlist" button at left will also be disabled.
    Phenotypic Data
    In combination with other aberrations

    Df(3R)Tl-X/Df(3R)ro-XB3 embryos show altered targeting of the ISNb pathway. The nerve endings at the cleft between muscles 6 and 7 are reduced in size, the nerve terminals synapsed to muscle M12 are greatly reduced and the nerve terminals synapsed to muscle M13 are expanded compared to controls.

    (Inaki et al., 2010)

    Inferred to overlap with: Df(3R)Espl3.

    (Cook and Carpenter, 2002)

    Df(3R)Tl-X/Df(3R)ro80b animals fail to hatch, but have no obvious morphological abnormalities in the gut, nervous system or musculature. The unhatched larvae do not perform normal hatching behaviour; the frequency of head swinging is reduced by 97% compared to wild type and reiterated cycles of head swinging are almost never seen, in contrast to wild type. On mechanical removal from the eggshell at 36 hours after egg laying, the larvae appear normal in morphology and respond to a touch on the side by twitching their bodies and retracting their heads, as is seen for wild-type larvae, although some mutant larvae are slower to respond. Df(3R)Tl-X/Df(3R)ro-XB3 embryos hatch.

    (Siekhaus and Fuller, 1999)

    Hemocyte density in the hemolymph of Df(3R)Tl-X/Df(3R)ro-XB3 larvae is significantly lower than in the hemolymph of control larvae.

    (Qiu et al., 1998)

    Df(3R)Tl-X/Df(3R)ro-XB3 transheterozygotes are Tl null embryos. RP3 motoneuron axon pathfinding is normal, but the growth cone often misinnervates non-target muscle cells. SNa growth cones develop normally but SNb growth cones lose targeting accuracy. SNb ending at muscle 15/16 cleft appear thicker than normal and innervation at muscle 6/7 cleft is often either missing or reduced in size.

    (Rose et al., 1997)

    Df(3R)ro-XB3/Df(3R)Tl-X embryos have an altered number of RP neurons. They have ectopically placed motor endings on muscles 6 and 7 and lack normal cleft endings.

    (Keshishian et al., 1993)
    NOT in combination with other aberrations

    In Df(3R)Tl-X/Df(3R)ro-XB3 embryos, 12.1% of hemisegments lack normal innervation of muscle fibers 7 and 6 (though innervation of muscles 15 and 16 is normal), and 29.4% of hemisegments have ectopic endings on muscle fibers 7 and 6 (compared to 0% for muscles 15 and 16). Aberrant numbers of RP motoneurons were detected in 15.5% of hemisegments per embryo, and the positioning of cells is noticeably more irregular than in wild type. The most common phenotype is a hemisegment missing one RP motoneuron in the position of either RP1 or RP4. 86% of mutant animals examined show this phenotype. Embryos and larvae (both Df(3R)Tl-X/Df(3R)ro-XB3 and deficiency heterozygotes) show an average of 46.1% of hemisegments per larva with one or more errors in the muscle pattern. Errors include duplications, missing fibers and misinserted fibers.

    (Halfon et al., 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    heterozygous females viable heterozygous females fertile

    Stocks (1)
    Notes on Origin
    Discoverer
     

    Revertant.

    (Anderson et al., 1985)

    Revertant

    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (15)
    References (52)