FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(3R)Delta-X43
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General Information
Symbol
Df(3R)Delta-X43
Species
D. melanogaster
Name
Deficiency (3R) Delta
FlyBase ID
FBab0002556
Feature type
chromosomal_deletion
Also Known As
Df(3R)DlX43, DlX43, Df(3R)Dl-X43, DysKX43
Computed Breakpoints include

91F11;92A11-92A13

Features within 91F11--92A13
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Vassin and Campos-Ortega, 1987)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Alton et al., 1988, Vassin and Campos-Ortega, 1987)
Breakpoints

91F11;92A8-92A10

(Vassin and Campos-Ortega, 1987)

91F11;92A11-92A13

(Alton et al., 1988)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << l(3)91Fa << Dl << bk2

Genetic mapping information
Comments
Comments on Cytology

Ref: FBrf0040185.

(Vassin and Campos-Ortega, 1987)

Limits of break 1 from polytene analysis (FBrf0046377) Limits of break 2 from polytene analysis (FBrf0048201)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Complementation Data
 
ort
(Gengs et al., 2002)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(3R)Exel6184/Df(3R)Delta-X43 flies show defects in cardiac function at both 1 and 5 weeks of age (systolic diameter is increased and fractional shortening is decreased compared to wild type).

    (Taghli-Lamallem et al., 2014)

    Df(3R)Delta-X43/Df(3R)Exel6184 flies (in which most Dys isoforms are absent) have a significantly shorter lifespan than wild-type controls, while single heterozygotes show a moderate lifespan reduction.

    (Taghli-Lamallem et al., 2008)

    Df(3R)Delta-X43/Df(3R)Exel6184 flies develop age-dependent abnormalities in the heart muscle throughout adult life, with increasingly disorganized myocardial myofibrils and gaps. With age, flies exhibit shorter diastolic intervals, resulting in increased heart rates and fewer asystoles, and produce a more regular heartbeat than wild-type controls.

    (Taghli-Lamallem et al., 2008)

    Expressing Mmus\DmdDp116.UAS under the control of Scer\GAL4how-24B rescues the increased systolic diameter and reduced fractional shortening of the heart wall in Df(3R)Delta-X43/Df(3R)Exel6184 adult flies.

    (Taghli-Lamallem et al., 2008)

    Throughout their adult life, Df(3R)Delta-X43/Df(3R)Exel6184 flies have a significantly wider diastolic and systolic diameter, accompanied by a reduced fractional shortening compared to controls, while single heterozygotes show increased diameter phenotypes without a reduction in fractional shortening.

    (Taghli-Lamallem et al., 2008)
    NOT in combination with other aberrations

    Df(3R)Delta-X43/+ mutant third instar larval eye discs do not show disrupted neuronal projections from photoreceptor neurons to the brain optic lobes.

    (Shcherbata et al., 2007)

    Small effect on the Brd1 and Brd3 bristle multiplication phenotype.

    (Leviten and Posakony, 1996)

    Transheterozygotes with sng- mutations are viable and phenotypically wild type.

    (Verheyen et al., 1996)

    Heterozygotes with Deltavi1 display an enhancement of the embryonic phenotype.

    (Vassin and Campos-Ortega, 1987)
    Stocks (0)
    Notes on Origin
    Discoverer

    Campos-Ortega.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (10)
    References (24)