FB2024_03 , released June 25, 2024
Recombinant Construct: P{UAS-aPKC.DN.CAAX}
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General Information
Symbol
P{UAS-aPKC.DN.CAAX}
FlyBase ID
FBtp0020715
Feature type
transgenic_transposable_element
Component Allele(s)
aPKCDN.UAS.Tag:CAAX(Unk)
Size
Expression Data
Associated insertion(s)
0 available
Molecular map
Description and Uses
Construct components
Component allele aPKCDN.UAS.Tag:CAAX(Unk)
Transgenic product class
dominant_negative_variant
(Sotillos et al., 2004)
missense_variant
(Sotillos et al., 2004)
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
aPKC
Description

UASt regulatory sequences drive expression of a membrane-targeted (by the CAAX motif) kinase-dead aPKC sequence. Carries the amino acid replacement K293W.

(Sotillos et al., 2004)

UASt regulatory sequences drive expression of a dominant-negative, kinase-dead form of aPKC (carries a K293W amino acid substitution in the ATP binding site) that is targeted to the membrane due to the presence of a Tag:CAAX(Unk) tag.

(Sotillos et al., 2004)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (13)
Reported As
Symbol Synonym
P{UAS-aPKC.CAAXDN}
P{UAS-aPKC.DN.CAAX}
(FlyBase, 1996-)
UAS-DaPKCCAAXDN
(Sotillos et al., 2004)
UAS-aPKC-CAAX-DN
(Koehler et al., 2022)
UAS-aPKC-DN
(Wang et al., 2018)
UAS-aPKC.CAAX.DN
(Schaub et al., 2019)
UAS-aPKC<up>CAAX K293W</up>
(Colosimo et al., 2010)
UAS-aPKCCAAX-DN
(Skwarek et al., 2014)
UAS-aPKCCAAXDN
(Carrasco-Rando et al., 2023)
UAS-aPKCCAAXKD
(Lee et al., 2006)
aPKC-DN
(Lu and Bilder, 2005)
aPKC<up>CAAX DN</up>
(Gamblin et al., 2014)
aPKCDN
(Skwarek et al., 2014)
Secondary FlyBase IDs
    References (11)