NZ::hCASP3(p12) and hCASP3(p17)::CZ together form the two halves of a split cell ablation tool. NZ::hCASP3(p12) corresponds to the small p12 subunit derived from the Homo sapiens CASP3 gene (HGNC:1504), tagged via a small linker sequence (GGSG) at the N-terminal end with the NZ antiparallel leucine-zipper domain (ALKKELQANKKELAQLKWELQALKKELAQ). hCASP3(p17)::CZ corresponds to the large p17 subunit derived from the Homo sapiens CASP3 gene, tagged via a small linker sequence (GGSG) at the C-terminal end with the CZ antiparallel leucine-zipper domain (AQLEKKLQALEKKLAQLEWKNQALEKKLAQ). Interactions between the NZ and CZ leucine-zipper domains leads to oligomerization and reconstitutes an active caspase, resulting in genetic ablation where both components are expressed (PMID:17283333).